Titlebook: New Concepts in Anxiety; M. Briley,S. E. File Textbook 1991Latest edition Macmillan Publishers Limited 1991 depression.kinin.neuropharmaco

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Immunological Ecology of Anxiety and Stress,s no vent in tears makes other organs weep’. Fritz Zorn, the author of a literary work, the novel ., published in 1977, shared this intuition: a young man from Swiss upper middle class society, Mars, develops a malignant tumour. This discovery throws his life into turmoil and he says, ‘The tumour re

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The Neuropharmacology of 5-HT in Anxiety,ased, and the brain was just a plastic bag filled with Ringer solution in which neurotransmitters were dissolved and receptors floated about, everything seemed reasonably simple. Oh, how we were deluded! For me, the real challenge of this paper is to write anything about the intrinsic neuropharmacol

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5-HT Receptor Mechanisms in Human Anxiety,d that 5-HT receptor antagonists and inhibition of 5-HT synthesis prevented the ability of foot shock to suppress operant behaviour. The subsequent observation that the anxiolytic benzodiazepine oxazepam decreased 5-HT turnover lead to the suggestion that anxiolytic drugs work by inhibition of 5-HT

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5-HT1A Receptors in Anxiety,us of intense research during the last few years. This receptor type is located both presynaptically on the 5-HT cell bodies (somatodendritic receptors), predominantly in the dorsal and median raphe nuclei and postsynaptically, predominantly in the limbic system (Verge .., 1985; Weissmann-Nanopoulos

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Modulations of Central Serotonergic Neurotransmission by Chronic Ipsapirone in the Rat,s been the subject of considerable research for the last twenty-five years. Nevertheless, this field remains controversial as many conflicting results exist in the literature (see Chopin and Briley, 1987). Recently, the introduction of the non-benzodiazepine anxiolytics, buspirone, gepirone and ipsa

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Anxiogenic and Other Effects of mCPP, a 5-HT, 1C Agonist,nized (Kilpatrick .., 1987) and 5-HT. sites have also been proposed (Dumuis .., 1989). The 5-HT. and 5-HT. types have been divided into various subtypes on the basis of binding properties and 5-HT. and 5-HT. families have now been suggested by a number of groups (e.g. Schmidt and Peroutka, 1989). Th