Titlebook: New Aspects of the Role of Adrenoceptors in the Cardiovascular System; Festschrift in Honou Horst Grobecker,Athineos Philippu,Klaus Starke

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Presynaptic ,-Adrenoceptor Control of Transmitter Release from Vascular Sympathetic Neurones in Vitrtor agonists, while it is enhanced by α.-adrenoceptor antagonists seems overwhelming (Langer 1977, 1981; Starke 1977, 1981; Westfall 1977; Gillespie 1980; Vizi 1979). This has led to the autoreceptor theory, according to which noradrenaline release from sympathetic neurones is modulated by the neuro

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Adrenoceptors in the Myocardium: Mechanical and Biochemical Events Resulting from Their Stimulationct). They also lead to an increase in the rate of relaxation and, hence, to an abbreviation of the contraction (relaxant effect). The physiological relevance of the relaxant effects of the sympathomimetic agents has been fully recognized only recently; it permits adequate ventricular filling in the

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Regulation of Myocardial Contractility Via Adrenoceptors: Differential Mechanisms of ,- and ,-Adrenoexcitation which adjust the cardiac function to the momentary physical requirement. Molecules of the released catecholamines bind to adrenoceptors located on the outer surface of the myocardial cell membrane and initiate a series of biochemical processes, which result in the characteristic changes i

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The Functional Role of the Coexistence of ,,- and ,,-Adrenoceptors in the Human Heartat sympathomimetic agents evoked their effects on different tissues with different orders of potency. . .- and . .-Adrenoceptors differ in their relative affinities for the endogenous catecholamines noradrenaline and adrenaline. At . . .adrenoceptors, which mediate cardiac effects and lipolysis, nor

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