Titlebook: New Aspects of the Role of Adrenoceptors in the Cardiovascular System; Festschrift in Honou Horst Grobecker,Athineos Philippu,Klaus Starke

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978-3-642-71315-6Springer-Verlag Berlin Heidelberg 1986

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Involvement of Catecholaminergic Neurones of the Hypothalamus in Blood Pressure Regulationease of the neurotransmitter. If the transmitter were indeed involved in the homeostasis of blood pressure, then changes in blood pressure would be expected to modify the rate of transmitter release in brain areas involved in cardiovascular control, thus counteracting the blood pressure change.

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Adrenoceptors in the Myocardium: Mechanical and Biochemical Events Resulting from Their Stimulationct). They also lead to an increase in the rate of relaxation and, hence, to an abbreviation of the contraction (relaxant effect). The physiological relevance of the relaxant effects of the sympathomimetic agents has been fully recognized only recently; it permits adequate ventricular filling in the face of the increased heart rate.

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Adrenaline Reversal and Postjunctional ,-Adrenoceptorsnaline was reversed to a depressor response, but that relaxation of the uterus, also brought about by adrenaline, remained unaltered. Dale concluded that “paralysis of the normally preponderant motor elements allows the emergence of a normally masked inhibitor effect”.

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Pulmonary-Veins

Regulation of Myocardial Contractility Via Adrenoceptors: Differential Mechanisms of ,- and ,-Adreno well documented in the past two decades. It is beyond the scope of this paper to review the .-adrenoceptor-mediated mechanism in detail. It will be described only as far as is necessary to permit comparison with the rather different subcellular processes that appear to result from myocardial α-adrenoceptor stimulation.

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