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Titlebook: Neurotropic Viral Infections; Volume 2: Neurotropi Carol Shoshkes‘Reiss Book 2016Latest edition Springer International Publishing Switzerla

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The Pathogenesis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesisll line established from a patient with a T-cell lymphoma (Poiesz et al. 1980). Concurrently, two groups in Jamaica and Japan detected HTLV-1-specific antibodies in the cerebrospinal fluid (CSF) and serum of patients with a progressive myelopathy that was previously known as tropical spastic parapar
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HIVal threat and responsive biomedical research, in less than 50 years, our understanding and approach to HIV have transformed a fatal disease into a chronic disorder. However, in regions of greatest endemicity, there is an unmet need for access to care; accordingly, from a global perspective, HIV-rela
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Molecular Biology of JC Virus and the Human Demyelinating Disease, Progressive Multifocal Leukoencepifocal leukoencephalopathy (PML). JCV was first isolated in 1971 from the brain tissue of a patient suffering from PML. With the emergence of AIDS in the 1980s, the incidence of PML increased dramatically. There has been a rapid expansion in the number of the additional human polyomaviruses in recen
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The Pathogenesis of Varicella-Zoster Virus Neurotropism and Infectionx, as the primary infection in susceptible individuals. During primary infection, VZV gains access to sensory ganglia of the peripheral nervous system and establishes latency within neurons. VZV reactivation from latency causes herpes zoster, called “shingles,” and is associated with a vesicular ras
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Virus-Induced Demyelination: The Case for Virus(es) in Multiple Sclerosiside. There are over 64,000 citations in Pubmed dating back as far as 1887. Much has been learned over the past 129 years with a recent burst in therapeutic options (mostly anti-inflammatory) with newer medications in development that are neuroprotective and/or neuroreparative. However, with all thes
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Innate Immunity in Viral Encephalitispathogen-specific, but are in response to classes of molecular structures. Infections can be perceived both extracellularly and intracellularly by Pathogen Associated Molecular Patterns (PAMPs) and their host cell ligands, Pathogen Recognition Receptors (PRRs), among them, Toll-Like Receptors (TLRs)
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Neuroendocrine-Immune Interactions in Neurotropic Viral Infectionsef history of the field of psychoneuroimmunology and then provides examples of the impact of stress on two neurotropic viral infections: herpes simplex and Theiler’s virus..Psychological stress has been implicated in the development and progression of multiple sclerosis (MS), and one of the best mod
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