Titlebook: Neurotransmitter Transporters; Investigative Method Heinz Bönisch,Harald H. Sitte Book 2016 Springer Science+Business Media New York 2016 n

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Using High-Speed Chronoamperometry to Measure Biogenic Amine Release and Uptake In Vivo,rs (serotonin, dopamine, and norepinephrine) in the intact and living mammalian brain. Chronoamperometry belongs to a family of electrochemical techniques collectively known as voltammetry, the only techniques currently available for “real-time” measurement of neurotransmitter transporter activity i

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Immunohistochemical Methods for the Study of the Expression of Low-Affinity Monoamine Transporters curate vision of the precise localization of transporters as they occur within their native anatomical context in mammalian central nervous system, an essential prerequisite for understanding their function in vivo. Low-affinity monoamine transporters like organic cation transporters (OCTs) and plas

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Analysis of Neurotransmitter Transporter Posttranslational Modifications: Phosphorylation and Palmion and fatty acid modification of proteins is becoming more widely appreciated as a regulatory mechanism for many proteins. The dopamine transporter (DAT) is an integral plasma membrane protein that mediates reuptake of dopamine from the extraneuronal space and is subject to several posttranslationa

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Approaches for Investigating Transporter Endocytic Trafficking in Cell Lines and Native Preparationed transporter function, either via genetic manipulation or intrinsic to neuropsychiatric disorders, has a profound impact on behavior and synaptic homeostasis. Transporters are dynamically regulated by numerous intracellular signaling pathways, many of which acutely alter transporter plasma membran

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Organic Cation Transport Measurements Using Fluorescence Techniques,rescent organic cation 4(4-dimethylaminostyryl)-.-methylpyridinium (ASP.) due to its specific fluorescence properties is a valuable probe for studying transport mediated by transporters of organic cations. ASP. is accepted by many members of the family of organic cation transporters and can be utili

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