Titlebook: Neuropsychiatric Dysfunction in Multiple Sclerosis; Ugo Nocentini,Carlo Caltagirone,Gioacchino Tedesch Book 2012 Springer-Verlag Italia 20

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Book 2012devoted to depression, but the other main categories of disturbance are also described and discussed. The final section addresses cognitive dysfunctions since they represent some of the worst events that patients with multiple sclerosis can suffer and are intimately related to neuropsychiatric dysfunction..

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Euphoria, Pathological Laughing and Cryingunderstood; according to one of the first hypotheses it is determined by the loss of voluntary inhibition of a presumed center controlling laughing and crying located in the brainstem (disinhibition hypothesis), able to regulate breathing and facial movements associated with laughing and crying.

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be experienced by patients with multiple sclerosis. The first section is designed primarily to describe the general clinical aspects of multiple sclerosis, from epidemiology to assessment tools. The role of neuroimaging and especially MRI is then explained, and treatment approaches and rehabilitatio

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Clinical Presentationher dysfunctions (i.e., vegetative disturbances) are rare at the disease onset, but can be found in the vast majority of patients after some years of disease course. Symptoms like fatigue are difficult to be set but are undoubtedly frequent and are considered as more disabling than others by patients themselves.

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Neuropathologyth a progressive disease but also in patients with CIS and RR MS. Several classifications of the plaques based on the activity level of pathological processes, disease stage and supposed pathogenetic processes have been proposed.

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