Titlebook: Neuroprotection and Regeneration of the Spinal Cord; Kenzo Uchida,Masaya Nakamura,Yoshiaki Toyama Book 2014 Springer Japan 2014 OPLL.biome

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Microenvironment Within the Injured Spinal Cord Focusing on IL-6reactions) and glial scar formation, facilitating functional recovery. In this paper, we present the data from this investigation and discuss the relationship between IL-6 signals and spinal cord injury.

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Autophagy in Spinal Cord Injury: Pathogenic Roles and Therapeutic Implicationsed neural tissue damage and locomotor impairment. These findings indicated that autophagic activity is increased in damaged neural tissue after SCI. Furthermore the promotion of autophagy by rapamycin treatment can provide neuroprotective effect to improve locomotor function following SCI. Here, we

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The Role of the Endoplasmic Reticulum Stress Response in Neural Apoptosis of the Injured Spinal Cord the administration of amiloride in vivo, and their effect on apoptosis was studied. Amiloride is a Food and Drug Administration (FDA)-approved potassium-sparing diuretic used to treat hypertension, which has been reported to control ER stress and improve several neurological disorders in vivo. The

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Roles of Microglia in Spinal Cord Injuryeatment of spinal cord injury by controlling microglia functions. Here, we review experimental works, both in vivo and in vitro, on the complex and varied responses of microglia in terms of both detrimental and beneficial effects.

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Biomechanics of the Spinal Cord and the Pia Mater large amount of strain energy, which enables shape restoration after decompression. The length of the spinal cord was decreased by 9.7 % after the separation to remove longitudinal tensile stress. The tensile stress along the craniocaudal axis in the spinal cord did not affect the spinal cord defor

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Morphologic Change and Glial Response to Unilateral Spinal Cord Compressionnterior funiculus significantly increased in the compressed half. There were no significant differences in the densities at the lateral and dorsal funiculi between the compressed and contralateral halves. The tissue damage in the gray matter of the compressed half was markedly higher. These findings

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Morphological Changes in Anterior Horn Cells, Immunoreactivity to Neurotrophic Factors, and Neuronale speculate that the presence of BDNF and NT-3 in neurons and astrocyte-like cells is proportionate to the severity of chronic mechanical compression and may contribute to the heterotropic neuronal reserve and survival. The numbers of TUNEL-positive neurons in the gray matter and oligodendrocytes in

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In Vivo Tracing of Neural Tracts in Tiptoe-Walking Yoshimura Mice by Diffusion Tensor Tractographydepending on the severity of the compression of the spinal cord. Quantitative analysis of sequential DTT enabled to detect subtle damage of the compressed spinal cord prior to the deterioration of neurological function in . mice. Thus, in a clinical setting, DTT could be a new effective imaging moda