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Titlebook: Neuroprotection; Method and Protocols Swapan K. Ray Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive license to S

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Chromatographic Separation and Quantitation of Sphingolipids from the Central Nervous System or Any has been developed to identify and characterize the sphingolipid composition(s) using a small amount (30 mg) of biological sample. Sphingolipids (lipids containing sphingosine or dihydrosphingosine) are well-known regulators of the central nervous system development and play a critical role in neur
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Role of Network Pharmacology in Prediction of Mechanism of Neuroprotective Compounds, using various bioinformatic tools and databases. Emerging studies have indicated the use of network pharmacological approaches in various research fields, particularly in the identification of possible mechanisms of herbal compounds/ayurvedic formulations in the management of various diseases. Thes
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Role of Serotonergic System in Regulating Brain Tumor-Associated Neuroinflammatory Responses,well as indirectly by modulating the immune cells. In the brain, serotonin plays a key role in regulating various functions; disturbance of the normal activities of serotonin leads to various mental illnesses, including the neuroinflammatory response in the central nervous system (CNS). The neuroinf
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Impacts of Omega-3 Fatty Acids, Natural Elixirs for Neuronal Health, on Brain Development and Functtion as precursors for many lipid-based biological messengers. Also, studies suggest the role of these fatty acids in regulating healthy sleep cycles, cognitive ability, brain development, etc. Dietary intake of essential poly unsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) and do
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Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis,ocytose damaged neurons, extracellular Amyoid-β, and Tau deposits. Several Tau internalization mechanisms of microglia have been studied which include phagocytosis, pinocytosis, and receptor-mediated endocytosis. In this chapter, we have visualized microglial phagocytic structures that are actin-ric
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,Internalization and Endosomal Trafficking of Extracellular Tau in Microglia Improved by α-Linolenicogenic Tau species are also known to display “prion-like propagation,” which explains their presence in extracellular spaces as well. Glial population, especially microglia, tend to proclaim neuroinflammatory condition, disrupted signaling mechanisms, and cytoskeleton deregulation in AD. Omega-3 fat
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,Quantitative Investigation of Neuroprotective Role of ROR1 in a Cell Culture Model of Alzheimer’s Dabilize the cytoskeleton (under pathological cues) is rare. Here, we describe how receptor tyrosine kinase-like orphan receptor 1 (ROR1), a receptor tyrosine kinase (RTK), can act as a neuroprotective molecule by promoting neurite outgrowth, stabilizing cytoskeletal components, and altering the dyna
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