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Titlebook: Neuromonitoring in Brain Injury; R. Bullock,A. Marmarou,J. Watson Conference proceedings 1999 Springer-Verlag Wien 1999 Amino acid.Calcium

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Unbound Plasma Concentrations May Predict Neuroprotective Brain Concentrations: A Brain Microdialysitration-time Curve; ffplasma = free fraction in plasma = unbound plasma) which represents the distribution of drug between plasma and brain, was determined to be unity within experimental error. These results suggest that unbound plasma concentrations may predict brain ECF concentrations of CI-977.
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Effect of Hypocapnea on CBF and Extracellular Intermediates of Secondary Brain Injuryrventilation did not cause a significant elevation of the extracellular lactate/pyruvate ratio or glutamate level in areas of the brain likely to be the most vulnerable to secondary injury. In spite of hyperventilation leading to a significant decline in local CBF in 20% of the trials, there was no
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Continuous Monitoring of Cerebrospinal Fluid Acid-Base Balance and Oxygen Metabolism in Patients witon and hypothermia was evaluated.... I) CSF acidosis was observed in all cases (minimum pH 6.59-7.17) due to increased CSF PCO. and/or decreased CSF HC0.- and tended to associate with abnormal ICP and/or CPP or ischemic episodes indicated by CSF P0. and S0., rS0., and/or Sj0. during monitoring. 2) I
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