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Titlebook: Neuroinflammation and Neurodegeneration; Phillip K. Peterson,Michal Toborek Book 2014 Springer Science+Business Media New York 2014 Alzhei

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Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson’s Diseaseon and oxidative stress influences the degeneration of dopaminergic neurons along the nigrostriatal axis during disease. Activated microglia that proximate degenerating neurons within the substantia nigra are a hallmark of PD. Other PD hallmarks include neuronal Lewy body inclusions composed primari
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Multiple Sclerosis: Impact on Functioning of the Blood–Brain Barriernumber of neurological disorders, dysfunction of the blood–brain barrier (BBB) is an apparent feature and may significantly contribute to disease progression. In particular, during the neuroinflammatory disorder multiple sclerosis (MS), the function of the BBB is severely hampered and immune cells g
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Neuroinflammation and Immune Regulation in Ischemic Stroke: Identification of New Pharmacological Tad with the increasing longevity and aging of the population. The incidence of ischemic stroke is highest in the elderly population, representing one of the most common causes of disability and mortality worldwide. Over the past decades, a tremendous amount of research has been undertaken into develo
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HIV/NeuroAIDS dysfunction ranging from mild impairment to frank dementia. Chronic HIV infection can result in neurodegenerative disease, overall termed neuroAIDS. HIV infection leads to neuronal dysfunction and neurodegeneration via the activation of brain macrophages/microglia, the presence of viral proteins, a
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Herpes Simplex Virus Infections of the Central Nervous Systempes simplex virus, type 1 (HSV-1), causes focal neurologic findings that are characteristic of temporal lobe localization. Herpes simplex encephalitis occurs in a biphasic age distribution with one-third of the cases less than 20 and the majority of remaining cases over 50. The diagnostic test of ch
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The Biology and Clinical Consequence of Infection with the Human Polyomavirus JCVose aspects that are not yet fully understood are explained..JCV virus is a human polyomavirus that leads to an asymptomatic infection in a large percentage of healthy individuals and can lead to a latent infection of the kidneys or the bone marrow. JCV reactivation and lytic infection of oligodendr
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