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Titlebook: Neuroendocrinology of Aging; Joseph Meites Book 1983 Plenum Press, New York 1983 endocrinology.neuroendocrinology.steroid.steroids.diabete

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978-1-4684-4525-1Plenum Press, New York 1983
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Changes in Hormone Uptake and Receptors in the Hypothalamus during Aging,SP). The oldest rats, 2–3 years of age, often exhibit an anestrous state, characterized by atrophic ovaries with only small or primary follicles and an infantile-appearing uterus (designated as ANE; Aschheim, 1964; Huang and Meites, 1975; Lu .., 1979).
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Changes in Ovarian Function and Gonadotropin and Prolactin Secretion in Aging Female Rats,ular estrous cycles are usually seen in animals older than 2 months of age. Between the ages of 2–12 months, most adult females display regular estrous cycles of 4- or 5-day duration, and this cyclicity is interrupted by a persistent-diestrous phase when the rat is in gestation, postpartum lactation, or in a pseudopregnant condition.
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The Reproductive Decline in Male Rats,oductive processes in the male rat, as well as the more common pathological findings seen in certain rat strains. Changes in hypothalamic neurotransmitter function and gonadotropin-releasing factor levels in relationship to male endocrine function have already been discussed in the chapter by Simpkins and will not be covered in this review.
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Relation of the Neuroendocrine System to Development of Prolactin-Secreting Pituitary Tumors,th advancing age, but in human subjects, PRL-secreting pituitary microadenomas occur in young, as well as older individuals, and may increase with aging (Post .., 1980). Whereas macroscopic pituitary tumors appear most frequently in aging rats and mice, such tumors are much less common in human subjects.
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Regulation of Thyrotropin Physiology during Aging,n of TSH. It is safe to conclude from all of these observations that age certainly has an influence on the parameters studied, but the information that has thus far emerged from studies in animals and man is incomplete and does not fall into a single pattern.
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