Titlebook: Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances; Aejaz Nasir,Domenico Coppola Book 2016 Springer Science+Bu

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Neuroendocrine Tumor Classification Systems: Gradingal features and aggressiveness of the tumor. Conversely, the term differentiation is used to reflect the degree of tumor resemblance to its nonmalignant counterpart..WHO has proposed a more scientific and clinically related tumor-based classification in 2000. The WHO classification suggests that neu

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Differential Diagnosis of Neuroendocrine Tumorsan. GI NET may present as well-differentiated neoplasms, further classified in grade 1 and grade 2 depending on the presence or absence of necrosis and on mitotic activity; or they may present as grade 3 neuroendocrine carcinomas which include large cell and small cell carcinoma. This chapter will b

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Gastroenteropancreatic: Poorly Differentiated Neuroendocrine Carcinomat HG-NECs arising in the squamous-lined GI tract (esophagus and anal canal) are small cell type (78 %), while majority of those involving the glandular GI mucosa are large cell (53 %) or mixed (82 %). Colorectal NECs (especially SCCs) often show Rb protein loss and alterations in p53 and show higher

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