Titlebook: Neurodevelopmental Pediatrics; Genetic and Environm David D. Eisenstat,Dan Goldowitz,Jerome Y. Yager Textbook 2023 Springer Nature Switzerl

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Cecilia Lee,Melanie Pennern areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi

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Hsiang-Yuan Lin,Meng-Chuan Lain areas with direct clinical significance.The authors are ex.This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topi

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Overview of CNS Organization and Developmenty of neural development is the importance of synapse formation and modulation for the creation of functional excitatory and inhibitory neural circuits that underlie cognitive functions. The goal of this chapter is, therefore, to provide a background in the CNS development and organization underlying

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Neural Induction and Regionalizationrogenitors. These findings may be more readily applied to the treatment of disorders of the developing nervous system as well as neurodegenerative diseases. Examples of disorders of neural induction, early regionalization, and patterning are discussed, including holoprosencephaly, neural tube defect

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Neural Stem Cells, Differentiation, and Migrationonal heterogeneity of NSCs and the niche factors that regulate their behaviour including age, injury, and disease. Exploiting NSPCs for neuroplasticity and neural repair has been at the forefront of regenerative medicine strategies. With both exogenous and endogenous cell-based approaches, a number

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Epigeneticssses, such as synaptic plasticity and responses to stimuli. With a combination of validated models and new technologies, further studies will be able to go beyond correlation and assess causation, and thus provide insights into the roles of epigenetics in neurodevelopment. Taken together, this chapt

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The Impact of an Adverse Intrauterine Environment on Neurodevelopmentd responses to subsequent inflammatory stimuli later in life. Indeed, this sustained immune hyperreactivity leaves both the immature brain and immune system vulnerable over extended developmental periods. Primary sequelae of severe and persistent intrauterine inflammation can manifest as a broad spe