Titlebook: Neurodevelopmental Disorders; Employing iPSC Techn Emanuel DiCicco-Bloom,James H. Millonig Book 2020 Springer Nature Switzerland AG 2020 iP

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nvironment and development is essential for survival under conditions that are ever changing. The light environment is a particularly important determinant of plant development and the periodicity, direction, quantity and quality of incident light are continuously monitored by plants. Regulatory lig

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Modeling Neurodevelopmental Deficits in Tuberous Sclerosis Complex with Stem Cell Derived Neural Prlopment of non-malignant cellular overgrowths, called hamartomas, in different organs of the body. TSC is also characterized as a neurodevelopmental disorder presenting with epilepsy and autism, and formation of cortical malformations (“tubers”), subependymal giant cell astrocytomas (SEGAs), and sub

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IPSC Models of Chromosome 15Q Imprinting Disorders: From Disease Modeling to Therapeutic Strategiesely from one parental allele. Several genes within the 15q11-q13 region are expressed exclusively from the paternally inherited chromosome 15. At least one gene ., shows exclusive expression of the maternal allele, but this allele-specific expression is restricted to neurons. The appropriate regulat

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Using iPSC-Based Models to Understand the Signaling and Cellular Phenotypes in Idiopathic Autism an ASD can also affect language, a uniquely human capability, and is caused by abnormalities in brain development. Traditionally obtaining biologically relevant human cells to study ASD has been extremely difficult, but new technologies including iPSC-derived neurons and high-throughput omic technique

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Dysregulation of Neurite Outgrowth and Cell Migration in Autism and Other Neurodevelopmental Disordnia (SCZ), intellectual disability (ID), and bipolar disorder (BPD) has been hampered by the inability to study human neurons, the heterogeneity of these disorders, and the relevance of animal model systems. Moreover, a majority of these developmental disorders have multifactorial or idiopathic (unk

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Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder,ify novel approaches and pathways involved in BP, we have obtained skin samples from BP patients and undiagnosed control (C) individuals, reprogrammed them to form induced pluripotent stem cells (iPSC), and then differentiated the stem cells into astrocytes. RNAs from BP and C astrocytes were extrac