Titlebook: Neurodegenerative Disorders; A Clinical Guide Orla Hardiman,Colin P. Doherty,Peter Bede Book 2016Latest edition Springer International Publ

Foreshadow

Parkinsonism-Plus Syndromes,es of the four main Parkinsonism-Plus disorders: Multiple Systems Atrophy [MSA], Progressive Supranuclear Palsy [PSP], Corticobasal Degeneration [CBD] and Dementia with Lewy Bodies [DLB]. The diagnosis remains clinical and vigilant neurological monitoring along with a strong multidisciplinary team support are the cornerstone of management.

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Palliative Care and End of Life Care,l be 2–3 years but 25 % will be alive at 5 years and 10 % at 10 years whereas multiple sclerosis (MS) will have a much longer prognosis which may be over 20 years. However, at some time during the disease progression palliative care may be appropriate.

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Fronto-Temporal Dementia (FTD),chnology. We outline current treatment options and discuss potential future therapies currently under investigation in the context of our rapidly increasing understanding of underlying disease patho-mechanisms in this disorder.

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,Huntington’s Disease,o slow the pace of neurodegeneration, which generally has a 20-year course after initial diagnosis. The clinical manifestations of the disease vary widely but they generally include dysfunction in cognition, mood, voluntary motor control and most patients have the signature finding of chorea.

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Managing Neuropsychiatric Symptoms of Neurodegenerative Diseases,gement of neuropsychiatric symptoms in neurologic disease remains challenging. This chapter explores the neurobiology of the common neuropsychiatric symptoms encountered in clinical practice, and outlines current approaches toward their pharmacological and behavioral management.