Titlebook: Neurodegenerative Diseases; Clinical Aspects, Mo Daniela Galimberti,Elio Scarpini Book 2018Latest edition Springer International Publishing

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,Genetic Complexity of Early-Onset Alzheimer’s Disease,ia. We provide an overview for the molecular genetic findings available for early-onset AD; discuss how this knowledge can be applied in clinical practice and highlight strategies to detect novel AD genes.

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,Risk Factors and Prevention in Alzheimer’s Disease and Dementia, and healthy lifestyles. In this chapter, we summarize the major findings concerning risk and protective factors for dementia and AD, based on current epidemiological evidence from observational and interventional studies. We also discuss the impact of ongoing interventional studies testing the effect of preventive measures for dementia and AD.

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Autosomal Dominant Frontotemporal Lobar Degeneration: From Genotype to Phenotype,nd age at disease onset. In addition, other genes are linked to rare cases of familial FTLD. Moreover, the use of next-generation sequencing approach allowed the identification of disease modifier (risk) genes such as common variants in the transmembrane protein 106b.

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Rare Dementias,a great importance, since some of them are treatable and reversible dementias..This chapter presents a comprehensive summary of etiologies, clinical presentation, typical features, diagnostic strategies, and treatments of known uncommon dementias.

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,Diagnosis of Alzheimer’s Disease Typical and Atypical Forms,tion, are currently implemented by the use of biomarkers and neuroimaging data. Moreover, the possibility of atypical forms, presenting with the involvement of different cortical areas, is taken into consideration..Herein, the main diagnostic tools for AD are revised; atypical AD presentations and possible diagnostic pitfalls are also discussed.

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,Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models, involved in disease has markedly increased the spectrum of available FTLD mouse models. This chapter provides an overview of APP and tau-based mouse models of AD and FTLD and how these models have advanced our understanding of disease mechanisms as well as discusses more recent FTLD models of novel disease genes.