Titlebook: Neurodegenerative Diseases; Pathology, Mechanism Philip Beart,Michael Robinson,Nicholas J. Maragaki Book 2017 Springer International Publis

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Motoneuron Disease: Basic Scienceis of voluntary and respiratory muscles. The unprecedented rate of discoveries over the last two decades have broadened our knowledge of genetic causes and helped delineate molecular pathways. Here we critically review ALS epidemiology, genetics, pathogenic mechanisms, available animal models, and i

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Motoneuron Disease: Clinicalere is significant heterogeneity with regard to anatomical and temporal disease progression. Importantly, more recent advances in genetics have revealed new causative genes to the disease. New efforts have focused on the development of biomarkers that could aid in diagnosis, prognosis, and serve as

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Stroke: Basic and Clinicalssel. Now, advances in clot retrieval (stentriever), in concert with tPA, heralds new optimism for ischemic stroke victims, but adds more pressure to identify therapies that will minimize hypoxic damage, protect compromised cells, and promote rehabilitation. In the past preclinical investigations ha

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Epileptic Encephalopathies as Neurodegenerative Disordersn, resulting in a broad range of neurological and non-neurological comorbidities. The concept of epileptic encephalopathies entails that the encephalopathy aspect of the overall condition is primarily driven by the epileptic activity of the disease, which often manifests as specific and pathological

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Neurodegeneration and Pathology in Epilepsy: Clinical and Basic Perspectivested electrographic seizures. These most prominently include neuron loss and an increase in astrocyte number and size but may also include enhanced blood–brain barrier permeability, the formation of new capillaries, axonal sprouting, and central inflammation. In animal models in which seizures are ei

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Prion Diseaseslular prion protein, with the misfolded conformers constituting an infectious unit referred to as a “prion”. Prions can spread within an affected organism by directly propagating this misfolding within and between cells and can transmit disease between animals of the same and different species. Prio

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Leukodystrophy: Basic and Clinicalher of myriad of supporting cells or tissues. With recent developments in neuroimaging, their presence is becoming increasingly noted even in situations where they were not suspected. More importantly, new genetic tools have improved our ability to diagnose. An understanding of pathogenesis is still