Titlebook: Neuroblastoma; M.A. Hayat Book 2012 Springer Science+Business Media B.V. 2012 Childrens tumor.Diagnosis ofchildren suffering from cancer.Q

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Neuroblastoma Mouse Modeloor even with intensive therapy. To develop new therapeutic agents, researchers have explored the molecular pathogenesis of neuroblastoma. Animal models of neuroblastoma are an indispensable tool for neuroblastoma research. This chapter reviews neuroblastoma mouse models, ranging from classic xenogr

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Orbital Metastasis in Neuroblastoma Patientsstein et al., 1992, J Clin Oncol 10:323–329; Castelberry, 1997, Pediatr Clin North Am 44:919–937). Recent advances in the understanding of tumor biology have aided in the diagnosis and medical management of this disease; however, cases of widespread metastasis, at times signaled by proptosis, ecchym

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Neuroblastoma: Triptolide Therapyprotein-70 (Hsp-70) is overexpressed in several human malignancies, and its inhibition has been shown to kill cancer cells. We have previously shown that triptolide, an inhibitor of Hsp-70, induces apoptotic cell death of pancreatic tumors. In this chapter, we explore the effectiveness of triptolide

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Neuroblastoma: Ornithine Decarboxylase and Polyamines are Novel Targets for Therapeutic Interventiontly there is no effective cure for high-risk NB, and the survival rate of relapsed/refractory patients is very low. . gene amplification in NB is associated with advanced stage disease, rapid tumor progression, poor prognosis, and resistance to therapy. Ornithine decarboxylase (ODC) is a rate-limiti

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Neuroblastoma: Perspectives for the Use of IL-21 in Immunotherapyactivity in several pre-clinical tumour models. In addition, clinical phase I-II trials have shown that IL-21 has an acceptable toxicity and induces immune-activation resulting in some clinical responses in patients with metastatic melanoma and renal carcinoma. Stage 4 neuroblastoma (NB) is frequent

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Neuroblastoma: Role of Hypoxia and Hypoxia Inducible Factors in Tumor Progressionand grow under hypoxic conditions. Thus, tumor cells have the ability to adapt to hypoxia, which highly affects the phenotype as well as behavior of distinct cells and the tumor as a whole. Instrumental in this adaptation process, which also occurs in non-transformed cells, are the hypoxia inducible