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Titlebook: Neurobiology of Central D1-Dopamine Receptors; George R. Breese,Ian Creese Book 1986 The Editor(s) (if applicable) and The Author(s), unde

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0065-2598 he recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of the
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Enantiomeric Analogues of SCH 23390 as New Probes for Behavioral Interactions between D1 and D2 Dop9; Seeman, 1980; Leff and Creese, 1983; Waddington, et al., 1986) arose in the absence of selective D. antagonists. Therefore, such a drug was clearly required to substantiate any functional distinctions between these subtypes, in the classical manner of previous schemes for heterogeneity in non-DAergic receptor populations.
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Biochemical and Behavioral Studies of D1 Dopamine Receptors Utilizing SCH 23390, receptors have been implicated as the site mediating the antipsychotic and antidopaminergic activity of neuroleptics (Creese et al., 1976; Seeman et al., 1976). By inference, D. dopamine receptors have been considered to mediate dopaminergic agonists’ behavioral effects as well (Seeman, 1981).
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Functional Interactive Effects of D1 and D2 Dopamine Receptor Blockade,unction for D. sites in brain is known, recent evidence has suggested an interaction between D. and D. sites. For example, SKF 38393, a D. agonist, stimulates the efflux of cAMP from superfused striatal tissue slices, and this stimulation is antagonized by LY 141865, a selective D. agonist.
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Electrophysiological Assessment of Dopamine Receptor Subtypes,mong neuronal systems. Therefore, electrophysiology serves as a bridge between the identification and anatomical location of a receptor, and the characterization of whole animal behaviors resulting from receptor activation.
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The Pathophysiological Functions Mediated by D1 Dopamine Receptors,d with D. or with both D. and D. DA receptors. In this presentation we will describe some behavioral responses which might be mediated by D. and/or by both D. and D. DA receptors, and we will discuss their clinical relevance.
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Ellen J. Hess,Ian Creesendern gegenüber. Aus heutiger Sicht wird deutlich, dass sie die Lebensprobleme der Kinder, die sie mit dem Begriff der „Verwahrlosung“ belegten, häufig mit ihrem Konzept der Ersatzerziehung durch Handwerks- oder Lehrerfamilien, später durch Diakone, Diakonissen und Ordensbrüder und -schwestern nicht
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Richard B. Mailman,David W. Schulz,Clinton D. Kilts,Mark H. Lewis,Hans Rollema,Steven Wyrickd Volk, so dass auch eine gesellschaftliche Dimension angesprochen ist. Die subjektive Seite der Selbstbildung ist auf das Soziale bezogen, das im Einsatz für Abstinenz und damit letztlich für die körperliche und geistige Gesundheit im Volk besteht. Von daher lag es für nicht wenige Mitglieder des Q
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