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Titlebook: Neurobiology of Central D1-Dopamine Receptors; George R. Breese,Ian Creese Book 1986 The Editor(s) (if applicable) and The Author(s), unde

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书目名称Neurobiology of Central D1-Dopamine Receptors
编辑George R. Breese,Ian Creese
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Neurobiology of Central D1-Dopamine Receptors;  George R. Breese,Ian Creese Book 1986 The Editor(s) (if applicable) and The Author(s), unde
描述Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 recep
出版日期Book 1986
关键词behavior; biology; neurobiology; receptor; schizophrenia
版次1
doihttps://doi.org/10.1007/978-1-4684-5191-7
isbn_softcover978-1-4684-5193-1
isbn_ebook978-1-4684-5191-7Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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The Multiplicity of the D1 Dopamine Receptor,1976), stereotyped behaviors (Creese and Iversen, 1973), self-stimulation (Phillips and Fibiger, 1973), conditioned avoidance responding (Seiden and Carlsson, 1963), stimulus control (Ho and Huang, 1975), and feeding and drinking (Ungerstedt, 1971; Fitzsimons and Setler, 1975). It is not surprising,
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Dopamine D1-Receptor Binding in the Living Human Brain,in the brain by at least two types of receptors (Kebabian and Calne, 1979). By the activation of the dopamine D. receptor, dopamine stimulates the enzyme adenylate cyclase (Kebabian et al., 1972). Activation of the dopamine D. receptor is not, or is possibly negatively, coupled to a dopamine sensiti
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Enantiomeric Analogues of SCH 23390 as New Probes for Behavioral Interactions between D1 and D2 Dop., 1983; Hyttel, 1983; Cross, et al., 1983; O’Boyle and Waddington, 1984a), was an event eagerly awaited as the final piece in a psychopharma-cological jigsaw that had for some time remained incomplete. The now widely accepted designation of D. and D. subtypes of DA receptor (Kebabian and Calne, 197
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Functional Interactive Effects of D1 and D2 Dopamine Receptor Blockade,hose which stimulate the enzyme adenylate cyclase (D. sites) and those which are not directly linked to or suppress this enzyme (D. sites, Kebabian and Calne, 1978; Stoof and Kebabian, 1984). Until now, the functional effects of DA receptor activation in the brain have been attributed to drug action
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Interaction of D1 and D2 Dopamine Receptors in the Expression of Dopamine Agonist Induced Behaviorsnd the pathophysiology of human neuropsychiatric diseases for which these behaviors serve as animal models. Observation and quantification of stereotypic and nonstereotypic behaviors has been a standard research protocol since the earliest work on the central activity of amphetamine and related agen
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Electrophysiological Assessment of Dopamine Receptor Subtypes,enomenon, and those which attribute a function to the described phenomenon. These approaches are interdependent and both are essential for understanding the whole organism. Previous chapters in this volume provide reviews of the presence and distribution of subtypes of central dopamine (DA) binding
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