Titlebook: Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders; Novel Strategies for Michael S. Ritsner,Abraham Weizman Bo

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Neurosteroid: Molecular Mechanisms of Action on the GABAA Receptorpregnane molecule required for agonist action. However, the neurosteroid pregnenolone sulfate (PS) is a non-competitive GABA. receptor antagonist and inhibits GABA-activated Cl. currents in an activationdependent manner. 3β-hydroxy A-ring reduced pregnane steroids are pregnenolone sulfate-like GABA.

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Involvement of Neuroactive Steroids in Hippocampal Disorders: Lessons from Animal Modelsocess that exacerbates hippocampal neuropathology, according to: (1) decreased proliferation of neuronal progenitors in the subgranular zone (SGZ) of the dentate gyrus (DG); (2) astroglial reactivity, with increased expression of the glial fibrillary acidic protein (GFAP); and (3) decreased neuronal

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Estrogen Modulation of Visceral Nociceptionociception. Nociception is a balance of pro- and anti-nociceptive inputs that is subject to regulation depending on the state of the organism. The modulation of purinergic receptor- mediated increase in intracellular calcium concentration and attenuation of opioid receptors functions by estrogen obs

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Neuroactive Steroids: Effects on Cognitive Functionsoid medroxyprogesterone, given as postmenopausal hormone therapy, double the dementia frequency in 5 years. The neuroactive steroid allopregnanolone inhibits learning in rat studies. Chronically high cortisol and GABA-steroid levels give irreversible cognitive damages. During stress the production o

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Estrogen, Cholinergic System and Cognitionholinergic function, as well as neurite outgrowth and branching. Structural changes have been postulated as integral steps in cellular processes leading to information storage in the nervous system, and perhaps estrogen-induced neurite sprouting within cholinergic neurons could underlie the behavior

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Effects of Estradiol and DHEA on Morphological Synaptic PlasticityGABAergic axo-somatic terminals are affected, while in case of the hippocampus, estrogen induces the formation of spine synapses. Morphological and electrophysiological data show that synaptic remodeling could be very rapid. The neurosteroid dehydroepiandrosterone can also induce synaptic plasticity

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Dehydroepiandrosterone, as Endogenous Inhibitor of Neuronal Cell Apoptosis: Potential Therapeutic Imest that DHEA may act as an endogenous neuroprotective factor, during development and in adulthood. The decline of DHEA levels during ageing may leave the brain unprotected against neurotoxic challenges. The DHEA specific membrane binding sites conferring neuroprotection offer a new target for devel