Titlebook: Neuro-Immune Interactions in Neurologic and Psychiatric Disorders; Paul Patterson,Claude Kordon,Yves Christen Conference proceedings 2000

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Serotonin-Immune Interactions in Major Depression,arch indicated that depression is accompanied by signs of in vitro immunosuppression, such as decreased mitogen-stimulated lymphocyte proliferation (Kronfol et al. 1983) and natural killer cell activity (Irwin et al. 1987). Recently, a large body of evidence has been reported suggesting that major d

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Regulation of Cyclic AMP Synthesis in Microglial Cells and Possible Role of Cyclic AMP in Neuroprot be ascribed to the numerous substances that these cells can synthesize and release upon activation by a variety of stimuli, including cytokines, pro-inflammatory substances, neurotransmitters and viral proteins..Cyclic AMP (cAMP) is one of the major second messengers and is known to regulate severa

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,Cytokine and Anti-Inflammatory Drug Effects on Brain Trauma and Alzheimer’s Disease Pathology in Trrative disease. Cytokines mediate many of these interactions in injury and disease, and they may also play key roles in the developing and normal adult brain. Experiments using mice with targeted mutations in the gene for one of these cytokines, leukemia inhibitory factor (LIF), demonstrate that thi

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Neuroglial Activation in the Nervous System Following Injury: Role of Cytokines,e combination of knockouts and injury models provides a new approach to gain insight into the cellular and molecular activation cascade that regulates plasticity and regeneration in the lesioned nervous system. The facial nucleus of the brain stem following nerve transection has been used as an expe

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Sickness Behavior: A Neuroimmune-Based Response to Infectious Disease,are due to the effects in the brain of proinflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and represent the expression of a well-organized central motivational state. Based on the results of pharmacological and biochemical experiments, it is now apparent th

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Central Origin of IL-1, Produced During Peripheral Inflammation: Role of Meninges,lipopolysaccharide (LPS), data consensually demonstrated an increase of brain IL-1. mRNA after LPS treatment. Expression at the protein level has been much more widely debated, mainly in the cases of demonstrations assessed by methods using global extracts of brain tissues. We hypothesized that thes

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