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Titlebook: Neuraxial Therapeutics; A Comprehensive Guid Tony Yaksh,Salim Hayek Book 2023 Springer Nature Switzerland AG 2023 Intrathecal Drug Delivery

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发表于 2025-3-21 17:50:46 | 显示全部楼层 |阅读模式
书目名称Neuraxial Therapeutics
副标题A Comprehensive Guid
编辑Tony Yaksh,Salim Hayek
视频video
概述Covers basic principles, advanced clinical management, evidence-based approaches and translational research.Comprehensive, highly referenced,‘resource to intrathecal therapies.Authored by worldwide le
图书封面Titlebook: Neuraxial Therapeutics; A Comprehensive Guid Tony Yaksh,Salim Hayek Book 2023 Springer Nature Switzerland AG 2023 Intrathecal Drug Delivery
描述.This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics.  It reviews the historical evolution of this approach from its inception in the later 1800‘s to present day.   This amply referenced text covers basic discussions of spinal anatomy, embryogenesis,  neuraxial vascularity,  cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of  different intrathecal agents are explored in detail with particular reference to clinical correlates  in pain and spasticity.   Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery.   Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. ..Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find .Neuraxial Therapeutics.,  to be an invaluable guide to th
出版日期Book 2023
关键词Intrathecal Drug Delivery System; Intrathecal pump; Intrathecal opioid; Intrathecal baclofen; Pain; Spast
版次1
doihttps://doi.org/10.1007/978-3-031-39558-1
isbn_softcover978-3-031-39560-4
isbn_ebook978-3-031-39558-1
copyrightSpringer Nature Switzerland AG 2023
The information of publication is updating

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Thomas F. Fletcher,Shelle A. Malkmusrol, electrical engineering, mechanical engineering, machine learning, reliability, and preference models. This large coverage of practical optimization problems makes this text very useful to those working on and researching systems design. The intended audience includes industrial engineers, postg
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Sarah D. Cramer,Mark T. Buttems, tables and figures are numbered con­ secutively in each section and indicate, in addition, the section number. In cross references to other chapters the (latin) chapter number is put first. References to the bibliography are again by "author" plus "year" in parentheses. The bibliography again c
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The History of Spinal Drug Delivery: The Evolution of Lumbar Puncture and Spinal Narcosis,prompting the search for more ideal drugs, equipment, and injection techniques, which continues to this day. This chapter will focus on the first 50 years of the evolution of the neuraxial delivery of therapeutics.
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The History and Evolution of Intrathecal Drug Delivery: From the 1950s to the Present,ocus on managing chronic conditions. The growth in understanding spinal sensory/motor biology along with the development of novel delivery platforms have led us to the current advancing state of neuraxial therapeutic interventions for managing not just pain or spasticity but also neurodegenerative d
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CSF Flow Dynamics in Relation to Intrathecal Drug Transport,complex picture and conflicting information. Animal models, consistent with the behavioral effects of IT drugs, emphasize a highly restricted biodistribution when delivered as a small volume at low rates of infusion. Bench-top models mimicking the physical IT space and its pressure dynamics serve to
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Intrathecal Delivery of Viral Vector-Mediated Gene Therapy, off-target expression or effects of the therapeutic payload. Since covering all types of viral vectors is beyond the scope of this chapter, the use of recombinant adeno-associated virus for gene therapy was selected as the exemplar to highlight the different therapeutic liabilities in-depth.
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