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Titlebook: Nephrotoxicity; In Vitro to In Vivo P. H. Bach,E. A. Lock Book 1989 Springer Science+Business Media New York 1989 development.etiology.eva

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A Prospective Study of Proteinuria in Cadmium Workersrliest biological sign of Cd interference with kidney function. Cadmium can decrease the tubular reabsorption of low molecular weight proteins (< 40, 000 dalton), such as ß2-m and RBP, and it can also enhance the glomerular filtration of high molecular weight proteins (> 40, 000 dalton), such as alb
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Red Blood Cell Negative Charges as an Index of the Glomerular Polyanion in Chronic Cadmium Poisoningcules such as albumin (1). Loss of glomerular polyanion in clinical or experimental renal diseases is associated with an enhanced excretion of anionic molecules. Evidence has been presented by recent studies (2, 3) that the negative charges of the red blood cells (RBCs) membrane, as determined by th
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Some Considerations on Critical Concentration of Cadmium for Renal Toxicity in Ratsarly in the liver and kidney and during the life-long exposure a renal Cd concentration becomes higher than a hepatic Cd concentration, which often causes renal tubular dysfunction (Friberg et al., 1985). Thus, we need to know the critical concentration of Cd to obtain information on the safety marg
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Nephrotoxicity of Cadmium in Chickensmarawickrama, 1979; Webb, 1979). There are various common features such as bone demineralisation, hypercalcaemia, anaemia, hypertension, and accumulation of Cd. in the liver, then in other tissue, predominantly the kidney. Among the consequences of Cd. nephrotoxicity are various cellular and biochem
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Protective Effect of Low Concentrations of Mercury Against HgCl2-Induced Nephrotoxicitylular distribution or excretion of mercury. Six main overlapping classes of compounds have been used to protect against mercury nephrotoxicity, these including beta-blocking agents, diuretics, chelators, substances that induce metallothioneins, agents involving a competition with mercury for the sam
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Analysis of Unscheduled Dna Synthesis and S-Phase Synthesis in F344 Rat Kidney After in Vivo Treatmeess the issue of tissue-specificity. Tests that focus on tissuespecific responses such as the in vivo — in vitro unscheduled DNA synthesis (UDS) and S-phase synthesis (SPS) assays (Mirsalis, et al., 1985; Mirsalis, 1987) have been reasonably successful in the prediction of hepatocarcinogenic potenti
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