Titlebook: Neoplastic Transformation in Human Cell Culture; Mechanisms of Carcin Johng S. Rhim,Anatoly Dritschilo Book 1991 Springer Science+Business

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Neoplastic Transformation of Human Epithelial Cells by Ionizing Radiationhowever, very litter studies on radiogenic transformation of human epithelial cells, especially with high-LET radiation. Using energetic heavy ions, we have been able to transform human epidermal keratinocytes and mammary epithelial cells to various stages of transformation. Both cell lines are immo

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Effects of Ionizing Radiation on Human Papillomavirus Immortalized Human Bronchial Epithelial Cellsport on the radiogenic transformation of human epithelial cells (1). We have established immortalized, non-tumorigenic human bronchial epithelial cell lines following transfection with human papillomaviruses (HPV) 16 or 18 (2) and are employing them in experiments designed to identify genetic mechan

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An Inherited P53 Point Mutation in a Cancer Prone Family with Li-Fraumeni Syndromeibroblast DNAs from four family members--the proband, his brother, their father and a paternal aunt, yielded an identical point mutation in codon 245 in only one allele of the p53 gene. This mutation, involving G to A transition (G.C -> G.C) leads to substitution of aspartic acid for glycine at that

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p53, a Direct Target of Mutational Activation by Chemical Carcinogens?of tumor suppressor genes as negative regulators of cell growth is believed to lead to tumor development. Loss of function of these genes may occur in the germ line, their absence predisposing the individual to cancer. More frequently, progressive loss of function in tumor suppressor genes occurs th

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Immortalization and Tumorigenic Transformation of Normal Human Cervical Epithelial Cells Transfectedfrom foreskin or cervix were transfected with recombinant human papillomavirus (HPV) DNAs and a series of immortal cell lines were established. These cell lines contained integrated and transcriptionally active HPV DNAs, they were not tumorigenic in nude mice, and they retained the ability to underg

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