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Titlebook: Neoplastic Transformation in Human Cell Culture; Mechanisms of Carcin Johng S. Rhim,Anatoly Dritschilo Book 1991 Springer Science+Business

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书目名称Neoplastic Transformation in Human Cell Culture
副标题Mechanisms of Carcin
编辑Johng S. Rhim,Anatoly Dritschilo
视频video
丛书名称Experimental Biology and Medicine
图书封面Titlebook: Neoplastic Transformation in Human Cell Culture; Mechanisms of Carcin Johng S. Rhim,Anatoly Dritschilo Book 1991 Springer Science+Business
描述The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi­ mental model systems. A workshop on "neoplastic transformation in human cell systems in vitro: mechanisms of carcinogenesis" was held at the Georgetown University Medical Center, Washington, DC, on April 25-26, 1991. The aims of the workshop were to present the state-of-the­ art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver­ sion of normal cells to a neoplastic state of growth. The following topics were closely related to the theme of the workshops: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Factors modulating cellular transformation. 3. Usefulness of defined in vitro model systems for viral, chemical, and radiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans­ formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 spea
出版日期Book 1991
关键词Activation; DNA; aging; cancer; cancer research; carcinogenesis; carcinoma; cell; cell culture; mutation; onco
版次1
doihttps://doi.org/10.1007/978-1-4612-0411-4
isbn_softcover978-1-4612-6750-8
isbn_ebook978-1-4612-0411-4
copyrightSpringer Science+Business Media New York 1991
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Comparison of Human Versus Rodent Cell Transformation: Importance of Cell Aging the information gained from animal studies will extend to humans. However, a fundamental difference must exist between human and rodents in terms of neoplastic development because cancers generally arise in rodents after a few years whereas the same cancers require decades in humans. For example, t
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Use of Immortalized Human Keratinocytes for the Study of Squamous Differentiation and Mutagenesis system for quantification of DNA damage at a defined genetic locus and 2) determine new epithelial-specific phenotypes associated with malignant conversion. HK lines RHEK-1 and HPK-1A were established by immortalization by a hybrid of adenovirus 12 and simian virus 40 (Ad12-SV40) (1) or human papil
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Polyamine Metabolism in Human Epidermal Keratinocytes Transformed with AD12-SV40, HPV16-DNA and K-, though the specific role of these amines is still not well understood at the molecular level, recent studies have shown that their concentration is highly regulated and that polyamines are necessary for normal cell growth and differentiation (see reviews 1 – 3). The pathway of polyamine biosynthesis
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Transformation of Human Diploid Fibroblasts by Radiation and Oncogenestransformation .. Whether the progeny of this cell will eventually give rise to an invasive, malignant tumor depends upon a number of host and tissue factors. The malignant transformation of cells . is also a complex, multi-step process by which normal cells acquire the various phenotypic characteri
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Ionizing Radiation-Mediated Protein Kinase C Activation and Gene Expressiont. Genes encoding transcription factors are expressed immediately after x-ray exposure in the absence of de novo protein synthesis. c-., c-. and Egr-1 are expressed following irradiation of human normal tissue cells and tumor cell lines. Radiation-mediated expression of these immediate early genes i
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