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Titlebook: Neocarzinostatin; The Past, Present, a Hiroshi Maeda (Professor and Chairman),Kiyoto Edo Book 1997 Springer Japan 1997 SMANCS.antitumor pr

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书目名称Neocarzinostatin
副标题The Past, Present, a
编辑Hiroshi Maeda (Professor and Chairman),Kiyoto Edo
视频videohttp://file.papertrans.cn/663/662535/662535.mp4
图书封面Titlebook: Neocarzinostatin; The Past, Present, a Hiroshi Maeda (Professor and Chairman),Kiyoto Edo  Book 1997 Springer Japan 1997 SMANCS.antitumor pr
描述The 20th century has witnessed the great benefits of the development of antibi­ otics, which became a reality after World War IL More than 50 years ago I witnessed the miraculous therapeutic power of penicillin, when I was a student at the Tohoku University Medical School‘s Department of Bacteriology in Sendai, Japan. The late Dr. Kondo was a graduate student in the department at that time and developed the first crude penicillin preparation in Japan which was applied with dramatic results in two patients. Although there was patient-family consent at that time, ethics committees, randomization. mutagenesis tests, distribution studies, purity-criteria, and phar­ macokinetics were not yet in existence. Today, regulatory procedures have com­ plicated the whole drug-approval process. For example, any new antibiotics that have been proven effective in laboratory studies against gram-negative bacteria, as might exist in deadly plague bacteria, must still undergo a long and enormously costly regulatory process before they can be introduced to benefit society, and before government insurance can be applied.
出版日期Book 1997
关键词SMANCS; antitumor protein; cancer chemotherapy; endiyene; neocarzinostatin (NCS); antibiotics; cancer; chem
版次1
doihttps://doi.org/10.1007/978-4-431-66914-2
isbn_softcover978-4-431-66916-6
isbn_ebook978-4-431-66914-2
copyrightSpringer Japan 1997
The information of publication is updating

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书目名称Neocarzinostatin被引频次




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书目名称Neocarzinostatin读者反馈学科排名




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Solution Structure of Neocarzinostatin Determined by Homonuclear Two-Dimensional Nuclear Magnetic R chapter reviews the determination process of the three-dimensional structure of neocarzinostatin by the combined use of homonuclear two-dimensional nuclear magnetic resonance (NMR) and distance geometry calculations, which has been dramatically improved in the past decade. The protein moiety consis
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The Biochemical Mechanisms Involved in the Biological Effects Induced by Neocarzinostatin (NCS) andon. Before the discovery of the NCS chromophore (NCS-chrom), NCS was defined as an antitumor antibiotic composed of an acidic polypeptide (approximately 11000; pi 3.3). In 1990, a NCS-chrom associated with the NCS polypeptide (NCS-apoprotein) was discovered and identified as the molecule responsible
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Immunomodulating Antitumor Mechanisms of SMANCS,eocarzinostatin against various transplanted solid tumors in mouse models. As an antitumor mechanism of SMANCS in mice bearing solid tumors, the antitumor immunity stimulated by SMANCS was focused on these descriptions rather than the direct cytotoxic effect of SMANCS against tumor cells shown by ne
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Host-Mediated Antitumor Activity Induced by Neocarzinostatin and Its Polymer-Conjugated Derivative dication in Balb/c mice. Tumor eradication was induced by a single administration of NCS or SMANCS between 4 weeks and 1 day before tumor transplantation. Meth A was always eradicated after transient growth. These results suggested that Meth A was eradicated by host-mediated antitumor activity induc
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Pharmacological Uniqueness and Clinical Effects of Neocarzinostatin,n (NCS) are described. The uniqueness of NCS, compared with other drugs, is its very rapid urinary clearance, short plasma half-life, high level of accumulation in the urinary bladder, and reabsorption from the bladder into the circulating blood. The clinical efficacy of NCS against bladder cancer,
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