Titlebook: Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers; Multidisciplinary Ma Andrea Necchi,Philippe E. Spiess Book 2022 The

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FLAIL

Background: State-of-the-Art and Ongoing Developmentss. In the recent years, little has change in the surgical management of the locally advanced disease with the robotic approach that failed to demonstrate survival benefit over the traditional open surgery. Even if supported by level 1a evidence, neoadjuvant cisplatin-based chemotherapy continues to

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Clinical Case Debate: Neoadjuvant Checkpoint Inhibition Versus Standard Chemotherapyss, only 20% of all patients referred to RC are receiving NAC upfront, as recommended by international guidelines. Several barriers are hampering the use of platin-based chemotherapy such as patient ineligibility due to poor renal function, poor performance status, severe neuropathy, or heart failur

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In-Situ

Biomarkers Predicting Outcomes Before and After Neoadjuvant Immune Checkpoint Inhibition Therapy foresponse rates to neoadjuvant immune checkpoint inhibition therapy are similar to platinum-based neoadjuvant chemotherapy (NAC), suggesting intrinsic tumor biology plays an important role in treatment response. To improve patient selection to neoadjuvant checkpoint inhibitor therapy, molecular profil

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The Role of Circulating Tumor DNA Analyses Chim Acta 313(1–2):139–142, 2001; Schwarzenbach et al., Nat Rev Cancer 11(6):426–437, 2011). A fraction of the cfDNA may be circulating tumor DNA (ctDNA) that represents the DNA released from cancer cells, likely associated with cancer cell turnover (Wan et al., Nat Rev Cancer 17(4):223–238, 2017).

CURB

The Value of Tumor Sample Analyses Before and After Checkpoint Inhibition: Contextualizing the Treat), immune checkpoint inhibitors have shown promising results in this setting. Phase II and III data of neoadjuvant programmed cell death-1 (PD-1) receptor/PD-1 ligand (PD-L1) inhibitors are now available with biomarker analyses of pre- and posttreatment tumors to help guide precision-based treatment

APEX

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State-of-the-Art and Future Role of Molecular Biomarkers for Patient Selectionudied in the neoadjuvant setting before surgical treatment for localized tumors. In muscle-invasive bladder cancer, neoadjuvant chemotherapy (NAC) before radical cystectomy is the gold standard. However, more than half of patients are ineligible for NAC and less than 40% achieve pathological complet

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