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Titlebook: Nanotoxicology in Safety Assessment of Nanomaterials; Henriqueta Louro,Maria João Silva Book 2022 The Editor(s) (if applicable) and The Au

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书目名称Nanotoxicology in Safety Assessment of Nanomaterials
编辑Henriqueta Louro,Maria João Silva
视频video
概述Worldwide experts present the latest knowledge on nanotoxicology.Innovative approaches in synthesis/application of nanomaterials.Provides central knowledge for applying safe and sustainable nanotechno
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Nanotoxicology in Safety Assessment of Nanomaterials;  Henriqueta Louro,Maria João Silva Book 2022 The Editor(s) (if applicable) and The Au
描述.Since its advent, nanotechnologies are considered key enabling technologies that take advantage of a wide array of nanomaterials (NMs) for biomedical and industrial applications generating significant societal and economic benefits. However, such innovation increases human exposure to these substances through inhalation, ingestion or dermal contact raising public health concerns. Furthermore, the NMs’ specific physicochemical properties, that confer them unique beneficial characteristics, can also elicit nano-bio interactions leading to toxicity and concerns for public health. In addition, such properties can be affected by the surrounding matrix, particularly when incorporated in complex matrices such as food products, leading to secondary features potentially more relevant than primary characteristics for determining their toxicological outcome. These nano specific issues raise the question of whether the NMs may produce adverse outcomes that are not accounted for when usingconventional toxicological approaches to assess their safety...Such uncertainties about the safety of NMs for human health and the environment may hamper a faster and more widespread exploration of their pote
出版日期Book 2022
关键词Nanotechnology; Safety Assessment; Predictive toxicology; Adverse Outcome Pathways; Nano-bio interaction
版次1
doihttps://doi.org/10.1007/978-3-030-88071-2
isbn_softcover978-3-030-88073-6
isbn_ebook978-3-030-88071-2Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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Targeting Cancer by Using Nanoparticles to Modulate RHO GTPase Signaling and atypical RHO GTPases. The typical RHO family members include the classical RHOA, RAC1 and CDC42 proteins, which cycle between an active GTP-bound and inactive GDP-bound conformation, under the coordinated action of three types of regulators: GEFs, GAPs and GDIs. Atypical RHO family members have
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Nanocelluloses: Production, Characterization and Market only lab and pilot plants but already industrial sites) have been producing nanocelluloses. This new fibrous materials can be obtained from different raw-materials by different methodologies, leading to different types of nanocelluloses with, obviously, different characteristics. Nonetheless, techn
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New “Omics” Approaches as Tools to Explore Mechanistic Nanotoxicologyhanges constantly in response to a stimulus. Therefore, proteomics can identify changes in protein abundance and/or variability that lead to a better understanding of the underlying mechanisms of action of NM while discovering biomarkers. As to genomics, it is still not well developed in nanotoxicol
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Cellular and Molecular Mechanisms of Toxicity of Ingested Titanium Dioxide Nanomaterialsthe interactions of NMs with biological systems in the context of intestinal tract and digestion processes, at cellular and molecular level. The knowledge gaps identified suggest that the incorporation of a simulated digestion process for . studies has the potential to improve the model for elucidat
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Nanomaterial-Induced Extra-Pulmonary Health Effects – the Importance of Next Generation Physiologicaical responses are not often alike which can in part be attributed to the numerous limitations of traditional mono-cellular . test systems which are acting as a surrogate for a whole organ. In an attempt to address and highlight this important issue, this chapter will discuss the progress made in th
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