Titlebook: NF-kB in Health and Disease; Michael Karin Book 2011 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-

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,Control of NF-κB Activity by Proteolysis,iferation and programmed cell death. This versatility necessitates a highly complex and tightly coordinated control of the signaling pathways leading to their activation. Here, we review the role of proteolysis in the regulation of NF-κB activity, more specifically the contribution of the well-known

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,Macrophages and NF-κB in Cancer,crophage phenotype, from ‘classically’ activated macrophages that have important roles in inflammation and innate immunity, to ‘alternative’ macrophage activation that is associated with wound healing, angiogenesis, and immune-suppression. Most, if not all, solid tumors have a significant macrophage

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,NF-κB as a Target for Oncogenic Viruses,htly controlled through its cytoplasmic sequestration by specific inhibitors, IκBs. Various cellular stimuli induce the activation of an IκB kinase, which phosphorylates IκBs and triggers their proteasomal degradation, causing nuclear translocation of activated NF-κB. Under normal conditions, the ac

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,Inhibition of NF-κB Signaling as a Strategy in Disease Therapy, immune responses, cell growth and survival, and the expression of certain viral genes. Moreover, NF-κB activity is elevated in and contributes to the pathology of several human diseases, including many cancers and chronic inflammatory diseases. Therefore, there has been great interest in the charac

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