Titlebook: NASH and Nutritional Therapy; Kiwamu Okita (Professor and Chairman) Conference proceedings 2005 Springer-Verlag Tokyo 2005 Hepatitis.Hepat

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Masako Tsuchiya,Isao Sakaida,Mariko Okamoto,Kiwamu Okita

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Nonalcoholic Fatty Liver (NAFL): Overview, appear as ‘cryptogenic cirrhosis’. Lipid peroxidation of the excess oil in the liver appears to be the major pathogenic mechanism. The process appears to alter mitochondrial form and function. Initial treatment usually involves exercise and dietary modifications. Patients who fail this approach or

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Role of Leptin in Pathogenesis of NASH,platelet-derived growth factor (PDGF)-dependent proliferation of HSCs. Taken together, these findings lead to the postulation that leptin acts as a profibrogenic cytokine in the sinusoidal microenvironment. In conclusion, leptin most likely plays a pivotal role in the progression of hepatic fibrosis

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Genetic Background of Japanese Patients with Nonalcoholic Steatohepatitis (NASH),th biopsy-proven NASH and healthy controls were analyzed by the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Functional polymorphisms in MTP and MnSOD were revealed to be involved in determining susceptibility to NASH in Japanese.

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Predictors of Nonalcoholic Steatohepatitis in Japanese Patients: Thioredoxin and NASH,with FL. GBV was detectable in the serum of only one patient with NASH. SEN virus was detected in 50% (15/30) of the patients tested, but the prevalence was not significantly different between the two groups (42% [8/19] in FL and 64% [7/11] in NASH). The . gene was not detected in any patient.We con

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Clinical Features of Patients with Nonalcoholic Fatty Liver Disease,fied by the stage of fibrosis. The median age of the patients was 53 years, with a range of 10 to 83 years. There were 96 males and 97 females. Eighty-five percent of the patients had at least one of the features of the metabolic syndrome. Histologically, 29 patients had established cirrhosis. In re

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Nutritional Therapy in Patients with Liver Cirrhosis,as significantly decreased and the carbohydrate oxidation rate was significantly increased in both groups. As a result, the respiratory quotient (RQ) was significantly improved. There was also a significant correlation between the nonprotein respiratory quotient (npRQ) and the creatinine-height inde