Titlebook: N-Oxidation of Drugs; Biochemistry, pharma P. Hlavica (Full Professor of Pharmacology and Tox Book 1991 Chapman & Hall 1991 Drogen.Oxidatio

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Radioimmunoassay and other methods for trace analysis of ,-oxide compoundsde of a tertiary aliphatic amine such as trimethylamine, or tertiary arylalkylamine such as dimethylphenylamine, or heteroaromatic amine such as pyridine or quinoline. The first two types are referred to here as aliphatic tertiary amines. It is established that there are chemical and metabolic diffe

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Mechanism, multiple forms and substrate specificities of flavin-containing mono-oxygenasestionally versatile molecule that in different microenvironments carries out a variety of different biological redox functions. Most of these are well known and the present discussion will be restricted to a subgroup of flavin-dependent mono-oxygenases that catalyse the oxidation of an exceptionally

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Factors regulating the activity of the rabbit lung flavin-containing mono-oxygenaseZiegler, 1988). As is the case with the other major monooxygenase system, the cytochrome .-450-dependent mixed-function oxidase, FMO is found in highest concentration in liver and requires NADPH and 0. for activity. However, unlike the .-450 system, mammalian FMO is not inducible by phenobarbital, 3

冥界三河

Human pharmacogenetics of nitrogen oxidationshe microsomal mixed function mono-oxygenases, commonly referred to as the cytochrome P-450s but also several non-cytochrome .-450 enzymes including the cytosolic alcohol dehydrogenase and the microsomal flavin-containing mono-oxygenase, otherwise known as Ziegler’s enzyme. Although such enzymes medi

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Roles of aminium radical intermediates in the biotransformation of dihydropyridines, cycloalkylaminens, 1987; Nelson and Harvison, 1987Guengerich, 1988; Butler et al., 1989Shimada et al., 1989). Products of the oxidation of different amines include hydroxylamines, .-oxides, pyridines, dealkylation products and other compounds. A proper understanding of the catalytic mechanism of .-450 is important

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Molecular activation mechanisms involved in arylamine cytotoxicity: peroxidase productstonucleophilic groups on informational cellular macromolecules such as DNA (Miller, 1970). Much attention has been focused on the .-oxidation of arylamines and arylamides by cytochrome .-450-dependent hepatic mixed function oxidases. However, peroxidases (donor-H.O. oxidoreductases, EC 1.11.1.7) als

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