| 书目名称 | Multiple Testing Procedures with Applications to Genomics |
| 编辑 | Sandrine Dudoit,Mark J. Laan |
| 视频video | |
| 概述 | This book provides a detailed account of the theoretical foundations of proposed multiple testing methods and illustrates their application to a range of testing problems in genomics.Includes suppleme |
| 丛书名称 | Springer Series in Statistics |
| 图书封面 |  |
| 描述 | .This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. The methods are applied to a range of testing problems in biomedical and genomic research, including the identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments, such as microarray experiments; tests of association between gene expression measures and biological annotation metadata (e.g., Gene Ontology); sequence analysis; and the genetic mapping of complex traits using single nucleotide polymorphisms. ..The book is aimed at both statisticians interested in multiple testing theory and applied scientists encountering high-dimensional testing problems in their subject matter area. Specifically, the book proposes resampling-based single-step and stepwise multiple testing procedures for controlling a broad class of Type I error rates, defined as tail probabilities and expected values for arbitrary functions of the numbers of Type I errors and rejected hypotheses (e.g., false discovery rate). Unlike existing approaches, the procedures are based on a test statistics join |
| 出版日期 | Book 2008 |
| 关键词 | Annotation; Gene Ontology; Master Patient Index; Microarray; Resampling; SAS; Single Nucleotide Polymorphi |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-0-387-49317-6 |
| isbn_softcover | 978-1-4419-2379-0 |
| isbn_ebook | 978-0-387-49317-6Series ISSN 0172-7397 Series E-ISSN 2197-568X |
| issn_series | 0172-7397 |
| copyright | Springer-Verlag New York 2008 |
发表于 2025-3-21 18:19:43
