| 书目名称 | Molecular Genetics of Recombination |
| 编辑 | Andrés Aguilera,Rodney Rothstein |
| 视频video | |
| 概述 | Covers one of the most important topics in modern biology: recombination.Summarize all existing views on the topic and to put them into context.In-depth and up-to-date analysis of the chapter topics, |
| 丛书名称 | Topics in Current Genetics |
| 图书封面 |  |
| 描述 | .Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumor |
| 出版日期 | Book 2007 |
| 关键词 | DNA; Double-strand break Repair; Escherichia coli; Genome Instability; biochemistry; cell biology; conserv |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-540-71021-9 |
| isbn_softcover | 978-3-642-09005-9 |
| isbn_ebook | 978-3-540-71021-9Series ISSN 1610-2096 Series E-ISSN 1610-6970 |
| issn_series | 1610-2096 |
| copyright | Springer-Verlag Berlin Heidelberg 2007 |
发表于 2025-3-21 17:16:11
