Titlebook: Microglia; Physiology, Pathophy Marie-Ève Tremblay,Alexei Verkhratsky Book 2024 The Editor(s) (if applicable) and The Author(s), under excl

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Microglia and Systemic Immunityrain microenvironment. While traditionally regarded as a part of the innate immune system, recent research has highlighted their role in adaptive immunity. The CNS is no longer considered an immune-privileged organ, and increasing evidence suggests bidirectional communication between the immune syst

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Evolution of Microgliaa being the only CNS-resident immune cells was outdated by the identification of CNS-associated macrophages (CAMs) as CNS interface residents, who, most likely, accompanied microglia in evolution over the past million years.

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Progress in Structural and Functional In Vivo Imaging of Microglia and Their Application in Health arauma, or in neurodegenerative or neuroinflammatory diseases, microglial responses range from protective to harmful, underscoring the need to better understand their diverse roles and states in different pathological conditions. In this chapter, we introduce multiphoton microscopy and discuss recent

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