Titlebook: MicroRNA in Development and in the Progression of Cancer; Shree Ram Singh,Pranela Rameshwar Book 2014 Springer Science+Business Media New

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The Role of MicroRNAs in Hematopoietic Stem Cells and Leukemia Developmentn in the hematopoietic system. Profiling of normal and malignant hematopoietic cells, corroborated with a limited but growing number of functional studies, has demonstrated that miRNAs are critical regulators of HSC function, are dysregulated in leukemias, and likely play an important role in leukem

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MicroRNAs and Chronic Lymphocytic Leukemiadecreased miR-15a/16 on B-1 lineage development. Enforced overexpression of miR-15a/16 leads to almost exclusive B-2 development. These results suggest that decreased miR-15a/16 is critical for the development of B-1 cells and the progression to malignant B-1 clonal expansion.

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Epigenetic Regulation of microRNA Genes in Colorectal CancerA genes is a potentially useful biomarker for detecting CRC or predicting its outcome. Moreover, re-expression of the miRNAs could be an effective approach to cancer therapy, and unraveling the relationship between epigenetic alteration and miRNA dysregulation may lead to the discovery of new therap

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MicroRNAs in the Development and Progression of Kidney Cancern RCC. Here, we review our current understanding about the role of miRNAs in RCC by summarizing findings from various studies. Several miRNA-profiling studies have been conducted to identify specific miRNA signatures capable of distinguishing tumor from normal tissue, identifying RCC subtypes and th

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MicroRNA and Cancer Drug Resistancer cells that govern multiple aspects of cancer including drug sensitivity. These studies have provided evidence for specific miRNAs targeting signaling molecules involved in drug transport, drug metabolism, synthesis of ligands for receptors, drug-induced DNA damage response and apoptotic pathways,

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s are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in se978-1-4939-4491-0978-1-4899-8065-6