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Titlebook: MicroRNA Targeted Cancer Therapy; Fazlul H. Sarkar Book 2014 Springer International Publishing Switzerland 2014 Cancer Therapy.Drug Resist

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Modulating MicroRNA Expression for the Therapy of Pancreatic Cancer,ients. Consequently, it is necessary to identify new therapeutic targets such as microRNAs to help manage this disease. Interestingly, these short non-coding RNAs can negatively control the expression of hundreds of genes, and thus are key regulators of tumor progression and dissemination. In additi
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MicroRNA Targeted Therapy for Overcoming Drug Resistance, Reversal of EMT and Elimination of Cancer transition (EMT) and cancer stem cells (CSCs) characteristics. Several miRNAs including let-7, miR-15/16, miR-200, miR-34a, miR-143/145, miR-21, miR-155, miR-197, and miR-221/222 have been found to play crucial roles in the control of drug resistance, EMT, and CSCs in pancreatic and prostate cancer
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miRNA-Targeted Therapies in the Most Prevalent Pediatric Solid Tumors,mors are mostly of epithelial origin and linked to a sustained exposure to environmental carcinogenic agents, pediatric malignancies tend to be of hematologic, mesenchymal or nervous system origin and their etiology is often unknown. Despite the small number of cases of childhood versus adult cancer
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miRNA Regulation of DNA Damage Repair Proteins in Cancer Cells: Interplay of ATM, TRAIL and miRNA,chanisms. There are visible knowledge gaps related to current comprehensions about protein network that ultimately regulates decisions of DNA damage repair and apoptosis. Although evidence, in general, is sparse and fragmentary, merging knowledge links TRAIL mediated signaling, DNA damage repair and
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Systems Biology Approaches in the Design of Effective miRNA-Targeted Therapeutics,r sites of target mRNAs. A number of miRNAs have been recognized to be aberrantly expressed in cancer. These findings have led researchers to aggressively pursue miRNAs for cancer diagnostic and therapeutics. However, both identification and targeting of miRNAs is not very straight forward because e
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Sanila H. Sarkar,Aamir Ahmad,Sandeep Mittalin order to allow a safe operation of the train traffic. Interlockings are controlled by a software logic that relies on a generic software and a set of application data particular to the station under control. The verification of the application data is time consuming and error prone as it is mostl
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