| 书目名称 | MicroRNA Targeted Cancer Therapy | | 编辑 | Fazlul H. Sarkar | | 视频video | | | 概述 | Unique book focusing on microRNA targeted therapy for a variety of solid tumors.First book which documents systems biology and network modeling of miRNAs for cancer therapy.The chapters in this book i | | 图书封面 |  | | 描述 | Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple gen | | 出版日期 | Book 2014 | | 关键词 | Cancer Therapy; Drug Resistance; Solid Tumors; Targeted Therapy; microRNA | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-05134-5 | | isbn_softcover | 978-3-319-37606-6 | | isbn_ebook | 978-3-319-05134-5 | | copyright | Springer International Publishing Switzerland 2014 |
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发表于 2025-3-21 16:25:58
