Titlebook: MicroRNA Detection and Target Identification; Methods and Protocol Tamas Dalmay Book 2017 Springer Science+Business Media LLC 2017 array.mi

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Cell-Free Urinary MicroRNAs Expression in Small-Scale Experiments,d plasma along with urine are the most common sources of clinically well, almost noninvasively available samples containing various types of miRNAs. Here, we present a protocol for a small-scale study investigating expression of several candidate miRNAs. Small-scale experiments may be worth investig

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Peptide-Based Isolation of Argonaute Protein Complexes Using Ago-APP,anscriptional gene silencing. Mammalian miRNA-guided gene silencing pathways mainly lead to translational repression and mRNA destabilization. To facilitate these processes, Ago proteins bind members of the GW protein family, which form central interaction platforms for the recruitment of downstream

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Predicting Functional MicroRNA-mRNA Interactions,lecules interact with their target mRNAs to induce mRNA degradation and/or inhibit the translation of mRNAs into proteins. Therefore, identifying miRNA targets is an essential step to fully understand the regulatory effects of miRNAs. Here, we describe a regularized regression approach that integrat

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An Assessment of the Next Generation of Animal miRNA Target Prediction Algorithms,ent an opportunity for greater discovery and understanding of post-transcriptional processes, in particular, translational inhibition of transcripts by miRBP (microRNA-RNA binding protein) complexes. Not only have novel methodologies been developed for the direct sequencing of RBP-bound RNA, but a n

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The UEA Small RNA Workbench: A Suite of Computational Tools for Small RNA Analysis,as small RNAs (sRNAs). They act as guides for the sequence-specific transcriptional and posttranscriptional regulation of target mRNAs and play a key role in the fine-tuning of biological processes such as growth, response to stresses, or defense mechanism..High-throughput sequencing (HTS) technolog