Titlebook: Metronomic Chemotherapy; Pharmacology and Cli Guido Bocci,Giulio Francia Book 2014 The Editor(s) (if applicable) and The Author(s), under e

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Metronomic Chemotherapy Regimens Using Microtubule-Targeting Agents: Mechanisms of Action, PreclinicMTAs. We also present their effects on the immune system, which may contribute to the antitumour efficacy of MTA-based metronomic chemotherapy. Then, we review the results obtained with this type of therapeutic approach in preclinical models of human cancer, focusing on the most promising combinatio

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Metronomic Chemotherapy in Breast Cancersg for new applications of this therapeutic strategy. Biomarkers are being developed to identify reliable surrogate markers of response and also to identify the proper patients to be treated. Nowadays, there are several ongoing trials to identify the optimal regimen and schedule of metronomic chemoth

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Clinical Trials of Low-Dose Metronomic Chemotherapy in Castration-Resistant Prostate Cancerotherapy was found to be beneficial in almost 60 % of patients (mean clinical benefit rate of 58.08 ± 20.30). Severe treatment-associated side effects were rarely seen, with anemia being the most commonly reported. One comparative single-center study showed a superior safety profile and comparable b

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Metronomic Chemotherapy in Hematological Malignanciesn encouraging efficacy with metronomic chemotherapy in these disease categories, with generally low toxicity and cost. With the growing availability of the target-specific biological agents, some of which are specific for antiangiogenesis, it is conceivable that metronomic chemotherapy, either alone

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Metronomic Chemotherapy in Non-Small-Cell Lung Cancersystem function through the elimination of immune suppressive cells. Numerous studies have investigated the efficacy of metronomic strategy in NSCLC patients with very promising results. Several chemotherapeutic agents, such as vinorelbine, gemcitabine, cyclophosphamide, and docetaxel, have been tes

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Pharmacokinetics and Pharmacogenetics of Metronomic Chemotherapy in various tumors, it remains largely unknown which genetic backgrounds could affect or predict the clinical response of patients. Trials integrating pharmacokinetic and pharmacogenetics research are necessary to better evaluate the clinical benefit of metronomic chemotherapy.

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angerufen und ihr Verhalten insgesamt entscheidet wesentlich darüber, ob integrative oder desintegrative Tendenzen der multikulturellen Gesellschaft die Oberhand gewinnen werden. Natürlich ist zu berücksichtigen, daß die Zahl der nichtdeutschen Tatverdächtigen ständig steigt und Polizeibeamte von da

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