Titlebook: Metipranolol; Pharmacology of Beta Hanns-Jürgen Merté (Director of the Eye Infirmary Conference proceedings 1984 Springer-Verlag Wien 1984

Oratory

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,New Directions in Glaucoma Therapy — Introductory Speech at the Metipranolol Symposium,s. In the course of the decades there have been additions and modifications to our therapeutic choice of preparations but still those first substances introduced then have asserted their prominent position up to our times. This applies particularly to Pilocarpine. No matter what the principle of act

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Suitability of Metipranolol for Glaucoma Therapy from the Pharmacological Viewpoint,dministration to the eye, judged on the basis of its pharmacological properties but not with reference to efficacy from the clinical viewpoint. Beta-receptor blocking agents have now been used successfully for 15 years in glaucoma and to my understanding there cannot be any doubt about the basis eff

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Principles of Clinical Drug Trials,re it is available as a commercial product to the medical profession. In view of the updated rules governing the safety of drugs this is indeed a costly procedure and so it is not surprising that only one out of about 6,000 to 10,000 synthetisised substances is approved as a drug for clinical use. I

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The Local Anaesthetic Action of Metipranolol Versus Timolol in Patients with Healthy Eyes,e first products of this type was, however, hampered by the local anaesthetic side effect on the cornea, as beta-receptor blocking agents have a chemical structure that is similar to that of local anaesthetics. This also partly explains their membrane-stabilizing activity. As far back as 1972 Vale .

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Therapeutic Efficacy of Metipranolol Eye Drops 0.3% Versus Timolol Eye Drops 0.25%, dealing with the dynamics of the aqueous humour have been conducted. Ever since the pressure reducing effect was first described in 1970 [1], timolol represents the most widely used .-blocking agent. Timolol is to be classified along with the noncardioselective .-blocking agents, i. e. responsible

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,Efficacy and Tolerance of Metipranolol — Results of a Multi-center Long-term Study,e-reducing action similar to other .-blockers might also be observed over a prolonged period and whether metipranolol might, in consequence, prove to be suitable as a reliable pressure-reducing drug for the long-term treatment of open angle glaucoma.