找回密码
 To register

QQ登录

只需一步,快速开始

扫一扫,访问微社区

Titlebook: Methotrexate; Bruce N. Cronstein,Joseph R. Bertino Book 2000 Springer Basel AG 2000 cancer.diseases.medicine.pathogenesis.psoriasis.resear

[复制链接]
查看: 26180|回复: 44
发表于 2025-3-21 17:37:13 | 显示全部楼层 |阅读模式
书目名称Methotrexate
编辑Bruce N. Cronstein,Joseph R. Bertino
视频video
丛书名称Milestones in Drug Therapy
图书封面Titlebook: Methotrexate;  Bruce N. Cronstein,Joseph R. Bertino Book 2000 Springer Basel AG 2000 cancer.diseases.medicine.pathogenesis.psoriasis.resear
描述Although surprising, it seems fitting that a drug developed at the dawn of the era of rational drug design and therapeutics, methotrexate, should remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medicine is practiced in a number of speciality areas. First developed to treat malignancies, methotrexate is now commonly used to treat gynecological problems, inflammatory arthritis, skin disease and probably other ailments as well. This work is designed to give a broad overview of the history of methotrexate‘s development, its prior use and its current therapeutic uses. As discussed in Chapter I, aminopterin and methotrexate were designed to inhibit mammalian folate metabolism but the concept of folic acid antag­ onism was soon applied to the development of antibacterial and anti­ parasitic agents. Trimethoprim and sulfa drugs were among the first antibiotics developed and they also remain quite useful today for the treat­ ment of a variety of infections.
出版日期Book 2000
关键词cancer; diseases; medicine; pathogenesis; psoriasis; research; rheumatic diseases; rheumatism
版次1
doihttps://doi.org/10.1007/978-3-0348-8452-5
isbn_softcover978-3-0348-9573-6
isbn_ebook978-3-0348-8452-5Series ISSN 2296-6056 Series E-ISSN 2296-6064
issn_series 2296-6056
copyrightSpringer Basel AG 2000
The information of publication is updating

书目名称Methotrexate影响因子(影响力)




书目名称Methotrexate影响因子(影响力)学科排名




书目名称Methotrexate网络公开度




书目名称Methotrexate网络公开度学科排名




书目名称Methotrexate被引频次




书目名称Methotrexate被引频次学科排名




书目名称Methotrexate年度引用




书目名称Methotrexate年度引用学科排名




书目名称Methotrexate读者反馈




书目名称Methotrexate读者反馈学科排名




单选投票, 共有 1 人参与投票
 

1票 100.00%

Perfect with Aesthetics

 

0票 0.00%

Better Implies Difficulty

 

0票 0.00%

Good and Satisfactory

 

0票 0.00%

Adverse Performance

 

0票 0.00%

Disdainful Garbage

您所在的用户组没有投票权限
发表于 2025-3-21 22:10:32 | 显示全部楼层
发表于 2025-3-22 03:08:22 | 显示全部楼层
,The mechanisms of methotrexate’s action in the treatment of inflammatory disease,t studies suggest several potential mechanisms of action and new agents developed on the basis of these mechanisms are currently being studied. We will discuss here the biochemical mechanisms by which methotrexate may suppress the inflammation of rheumatoid arthritis.
发表于 2025-3-22 07:17:34 | 显示全部楼层
Use of methotrexate in the treatment of psoriasis and other dermatological disorders,common of this group of diseases, estimated to occur in 1-2% of western European populations [.], much of the discussion on the use of MTX in skin disease will be given to MTX and its use in psoriasis.
发表于 2025-3-22 11:12:19 | 显示全部楼层
2296-6056 hould remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medicine is practiced in a number of speciality areas. First developed to treat malignancies, methotrexate is now commonly used to treat gynecolog
发表于 2025-3-22 14:00:21 | 显示全部楼层
Methotrexate in rheumatoid arthritis,he accepted issues regarding the use of this compound in RA as well as those issues which are less well accepted, but also of concern to the practicing rheumatologist. We will, for the most part, focus on adult patients with RA. The reader is referred to a number of publications dealing exclusively with children with juvenile (J) RA or JRA [.-.].
发表于 2025-3-22 18:45:02 | 显示全部楼层
The use of methotrexate in gynecological practice,ies has become widely accepted and practiced in many centers around the world. In addition, methotrexate has been used to treat pregnancies implanted within a uterine scar and in patients with placenta accreta. However, in this chapter we will limit the discussion to the use of methotrexate in the treatment of ectopic pregnancies.
发表于 2025-3-22 22:39:07 | 显示全部楼层
Methotrexate, its mechanism of action in malignant disease and mechanisms of resistance by malignan alone or in combination, in the majority of tumors such as acute myelocytic leukemia (AML), intrinsic resistance effectively prevents the use of this agent. In malignancies which are initially sensitive to therapy, e.g. ALL, acquired resistance may develop contributing to treatment failure and relapse [.].
发表于 2025-3-23 01:33:25 | 显示全部楼层
ere die Mi­ kroprozessoren haben in den letzten Jahren eine stürmische Entwicklung erfahren und viele der Architekturkonzepte, die zunächst den Großrechnern vorbehalten wa­ ren, haben in die Architekturen der Mikroprozessoren Eingang gefunden. In anderen Worten, viele der grundlegenden Ideen, welche
发表于 2025-3-23 09:03:56 | 显示全部楼层
 关于派博传思  派博传思旗下网站  友情链接
派博传思介绍 公司地理位置 论文服务流程 影响因子官网 SITEMAP 大讲堂 北京大学 Oxford Uni. Harvard Uni.
发展历史沿革 期刊点评 投稿经验总结 SCIENCEGARD IMPACTFACTOR 派博系数 清华大学 Yale Uni. Stanford Uni.
|Archiver|手机版|小黑屋| 派博传思国际 ( 京公网安备110108008328) GMT+8, 2025-5-25 19:48
Copyright © 2001-2015 派博传思   京公网安备110108008328 版权所有 All rights reserved
快速回复 返回顶部 返回列表