Titlebook: Methods of Cancer Diagnosis, Therapy, and Prognosis; General Overviews, H M. A. Hayat Book 2010 Springer Science+Business Media B.V. 2010 O

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Pretargeted Radioimmunotherapy in Cancer: An Overviewormal cells selectively on the basis of antigenic differences between normal and abnormal cells. No clinical application of this concept took place until Pressman and Keighley (1948) utilized labeled antibodies for cancer detection. Pressman et al. (1957) showed that monoclonal antibodies (MoAbs) la

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Chemotherapy-Induced Neurotoxicityyelosupression and hypersensitivity reactions are largely amenable to treatment, chemotherapy-induced neurotoxicity remains a significant problem, with limited treatment options and no standardized diagnostic or management criteria. Receiving a full course of chemotherapy on schedule is a critical f

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Multidrug Resistanceent with advanced malignant lymphoma (Goodman et al. 1946). Although there are some types of cancer such as colon cancer which respond poorly, most cancers respond well to first-line chemotherapy. However, after a cancer-free period, in a percentage of cases cancer reappears and is termed relapse or

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Role of Antibodies in Cancer Treatment (An Overview)art drugs are more effective and less toxic because they discriminate better between normal and malignant cells. A naturally occurring smart drug is an antibody that has an exquisite specificity for its target antigen. The foundations for passive immunotherapy were laid at the end of the nineteenth

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Incorporating Pharmacogenomics into Cancer Therapydividual heterogeneity in drug treatment response and tolerance. The terms pharmacogenetics or pharmacogenomics, which are often used interchangeably, refer to the study of how an individual’s genetic inheritance affects the body’s response to drugs and the use of this genetic information to predict

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Translating In Vitro Cell Lines Result into Clinical Practiceed wide popularity in the study of cancer, because of the innate continuously proliferating nature of these cell lines. Cancer cell lines are obtained by the enzymatic digestion or explant growth of tumour specimens. The main advantage of using cell lines for such research is the immortal nature of

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Head and Neck Squamous Cell Carcinoma: Therapy with Fusaric Acid/Paclitaxel2007). Globally, HNSCC affects >500,000 patients each year, making it the 6th in incidence and the 7th in mortality in the world (Parkin et al. 2001, 2005). The chance of recurrence of advanced stage HNSCC within 2 years of treatment is > 50%. The risk of death from a second primary cancer in patien