Titlebook: Methods in Mammary Gland Biology and Breast Cancer Research; Margot M. Ip,Bonnie B. Asch Book 2000 Springer Science+Business Media New Yor

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Mouse Models for Mammary Cancerbreast cancer research. It is the intent of this overview to help clarify the contributions of traditional models of breast cancer and provide a rationale for the continued development of new models that more closely reflect the human disease.

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Chemical-Carcinogen-Induced Transformation of Primary Cultures of Mouse Mammary Epithelial Cells Gro fat pads of syngeneic female mice. Resultant mammary outgrowths are scored as to the development of morphologically distinct preneoplastic and neoplastic lesions. The phenotype and the nature of genetic lesions is greatly dependent on the mitogen used at the time of carcinogen exposure.

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the completion of this volume to allow acknowledg­ ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards s

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Methods for the Induction of Mammary Carcinogenesis in the Rat Using either 7,12-Dimethylbenz[α]anthtreatment of breast cancer. This chapter provides a detailed account of the methods utilized to implement the two most widely studied chemically initiated models of mammary carcinogenesis in the rat. They are induced by treatment of female rats with either 7,12-dimethylbenz[α]anthracene or 1-methyl-1-nitrosourea.