Titlebook: Metastasis of Breast Cancer; Robert E. Mansel,Oystein Fodstad,Wen G. Jiang Book 2007 Springer Science+Business Media B.V. 2007 BRCA.angiog

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BRCA1 in initiation, invasion, and metastasis of breast cancer: a perspective from the tumor microe are often diagnosed as high-grade, typically display a basal epithelial phenotype, and proliferate rapidly. While somatic mutations of . are rarely found in sporadic breast cancer cases, 30– 40% of the sporadic cases show reduced . expression, supporting the notion that impaired BRCA1 function may

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Cell motility and breast cancer metastasis,by the dynamic organisation of cytoskeletal components (actin micro-filaments and microtubules), establishment and disruption of cell-matrix and homotypic/heterotypic cell-cell adhesions, and extracellular proteolysis. Metastasis formation is not only related to cancer cell motility, but also necess

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