Titlebook: Metastasis of Breast Cancer; Robert E. Mansel,Oystein Fodstad,Wen G. Jiang Book 2007 Springer Science+Business Media B.V. 2007 BRCA.angiog

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Breast cancer secreted factors alter the bone microenvironment,n turn to secrete factors back onto the cancer cells. Inhibiting the actions of cancer-secreted factors may break this vicious cycle. The list of tumor-secreted factors is long, but they can be divided into three groups: (1) bone-resorbing, (2) bone-forming, and (3) metastasisopposing factors. These

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Molecular imaging in metastatic breast cancer,astatic breast cancer, FDG-PET imaging of tumour metabolism can be of value in selected cases, with its high sensitivity, but varying specificity. For response monitoring and prognostic evaluation, FDG-PET may be useful, but future studies are required to confirm this. Molecular imaging of tumour HE

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al skeleton, where the bone marrow remains red. Therefore, in adolescence and early adulthood bone changes are particularly common in the skull, pelvis, and spine. Pseudotumors of extramedullary hematopoiesis may occur in paravertebral sites and in many other organs and tissues [8, 22, 45, 57, 58].

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