Titlebook: Metals and Oxidative Damage in Neurological Disorders; James R. Connor Book 1997 Springer Science+Business Media New York 1997 Alzheimer.N

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Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury Directions for Therapeutic Intetially during asphyxia, blood flow to the brain increases to maintain cerebral energy metabolism until cardiac depression causes hypotension, bradycardia, and cerebral ischemia (Van-nucci, 1990). Unless prompt and effective resuscitation is achieved, the asphyxiated infant will die. Even when resusc

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,The Role of Oxidative Processes and Metal Ions in Aging and Alzheimer’s Disease,st of reviews summarizing the major biochemical changes associated with aging have been published over the last few years (Kehrer and Lund, 1994; Shigenaga and Ames, 1994; Ames ., 1993; Beal, 1993; Stadtman, 1992; Mooradian and Wong, 1991). Comprehensive lists of the panoply of age-related changes s

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Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Supclearly understood. A subset of FALS cases are caused by mutations in Cu/Zn superoxide dismutase 1 (SOD1) (Deng ., 1993; Rosen ., 1993), but the mechanism by which mutant SOD1 injure motor neurons is unclear. We have suggested that abnormalities in Cu. metabolism may play a role in disease (Wong .,

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Oxidative Stress-Induced Cell Damage in the CNS,eases described was unique in its symptoms, one common feature is present: Transition metals contribute to the pathological process by facilitating generation of reactive oxygen species (ROS). This concluding chapter will examine the cells and organelles at risk for oxidative damage and propose a fi

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Yelena Glinka,Michael Gassen,Moussa B. H. Youdimsciplinary context.Will appeal to all who are interested in Given that treatment with curative intent is possible in only one-half of cancer victims, and that such treatment frequently fails, the majority of patients with cancer will require relief of symptoms and signs caused by their disease. In t