Titlebook: Metals and Oxidative Damage in Neurological Disorders; James R. Connor Book 1997 Springer Science+Business Media New York 1997 Alzheimer.N

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Evidence for Iron Mismanagement in the Brain in Neurological Disorders,ical function. A deficiency in iron availability to the brain may directly affect the general metabolic activity of the brain by decreasing the function of cytochrome oxidase, glucose 6-phosphate dehydrogenase, NADH dehydrogenase, succinic dehydrogenase, and aldehyde dehydrogenase—all of which requi

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Magnetic Resonance Imaging of Brain Iron,ence is as high as 47% among those over age 85 (Evans ., 1989). Similarly, small age-related increases in neurofibrillary tangles (NFT) have been observed in brains of nonde-mented individuals (Price ., 1991; Morris ., 1991; Arriagada .., 1992). NFT density has been specifically associated with both

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Neurochemical Roles of Copper as Antioxidant or Prooxidant,apeutics, there is a long historical documentation of the use of copper salts in ointments for over 2000 years. The biological activity of copper was unknown at the time but was used for a wide variety of maladies including diseases of the skin, various infections, and recoveries from neurological d

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The Role of Zinc in Brain and Nerve Functions,60s (Prasad ., 1963). Severe growth retardation, hypogonadism in males, hepatosplenomegaly, rough and dry skin, mental lethargy, and susceptibility to infections were reported in zinc-deficient humans from the Middle East in 1963 (Prasad ., 1963).

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Delivery of Metals to Brain and the Role of the Blood-Brain Barrier,ently, eight metals, including calcium, magnesium, iron, copper, zinc, manganese, cobalt, and molybdenum, are known to be required for the normal development and function of the brian (Prohaska, 1987). Each must be supplied at specific levels to avoid signs of deficiency or toxic excess. Others, suc

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