Titlebook: Metallothioneins in Normal and Cancer Cells; Piotr Dziegiel,Bartosz Pula,Marzenna Podhorska-Oko Book 2016 The Editor(s) (if applicable) an

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Piotr Dziegiel,Bartosz Pula,Christopher Kobierzycki,Mariusz Stasiolek,Marzenna Podhorska-Okolow

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Introduction,he stratified squamous epithelia of the skin and upper parts of the respiratory tract (Quaife et al. 1994). Most of our knowledge concerning MTs’ biology stems from research focusing on the role of MT-1 and MT-2 isoforms (MT-1/2), which are ubiquitously expressed in almost all cells of the body (Dav

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Metallothioneins: Structure and Functions,, in which they are juxtaposed with lysine (Lys) and arginine (Arg) amino acid residues and arranged in two thiol-rich sites designated domains α and β (Fig. 2.1). The two metal-binding domains are separated by a non-cysteine-containing sequence often designated as the spacer or linker (Zangger et a

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Metallothionein-3,t al. 1991; Romero-Isart and Vasak 2002; West et al. 2008). Primarily in physiological conditions, abundant MT-3 expression has been observed in fibrous and protoplasmic cortical astrocytes (Aschner 1996a, b). Subsequently, its expression on the mRNA and protein levels was disclosed in peripheral or

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0301-5556 le in cell senescence progression.Clinical Application: HighThis book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement

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Book 2016is, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system. 

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0301-5556 pact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system. 978-3-319-27471-3978-3-319-27472-0Series ISSN 0301-5556 Series E-ISSN 2192-7065

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Book 2016des insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory