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Titlebook: Metabotropic Glutamate Receptor Technologies; M Foster Olive,Brian T. Burrows,Jonna M. Leyrer-Ja Book 2021 Springer Science+Business Media

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书目名称Metabotropic Glutamate Receptor Technologies
编辑M Foster Olive,Brian T. Burrows,Jonna M. Leyrer-Ja
视频video
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
丛书名称Neuromethods
图书封面Titlebook: Metabotropic Glutamate Receptor Technologies;  M Foster Olive,Brian T. Burrows,Jonna M. Leyrer-Ja Book 2021 Springer Science+Business Media
描述This volume highlights various techniques used to study multiple aspects of mGlu receptor function. Chapters in this book cover topics such as modern approaches for the development and screening of allosteric modulators; fluctuations in intracellular calcium induced by mGlu receptor activation; dopamine-glutamate interactions in the central nervous system; methods for assessing mGlu receptor localization; and common techniques for evaluating mGlu modulation in behavior in rodents, including stress and alcohol drinking. In the .Neuromethods. series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory..Cutting-edge and practical, .Metabotropic Glutamate Receptor Technologies. provides researchers with a starting point to address important questions regarding mGlu and its importance. Researchers working in the fields of neuroscience and physiology of multiple peripheral systems will find this volume most useful. .
出版日期Book 2021
关键词mGlu; PET imaging; recombinant systems; synaptic plasticity; optogenetic
版次1
doihttps://doi.org/10.1007/978-1-0716-1107-4
isbn_softcover978-1-0716-1109-8
isbn_ebook978-1-0716-1107-4Series ISSN 0893-2336 Series E-ISSN 1940-6045
issn_series 0893-2336
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2021
The information of publication is updating

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Electrophysiological and Calcium Imaging Approaches to Study Metabotropic Glutamate Receptors, resistance. Activation of mGluR, however, does not directly cause charge movement across the plasma membrane, and thus cannot be directly measured in an electrophysiological recording. Instead, mGluR activation can affect numerous downstream targets, many of which are ion channels that can be studi
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Optical Approaches for Modulating mGlu Receptor Activity, individual mGlu subtypes has traditionally relied on pharmacological approaches, which have proven difficult due to many factors including inadequate selectivity for specific receptor subtypes, a lack of discernment in receptor modulation across different cell types, and a lack of spatial and tempo
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Classic and Modern Approaches to Investigating Interactions Between Dopamine Systems and Metabotropysiology and behavior. The anatomical distribution of these receptors in the central nervous system (CNS) allows for extensive interaction between mGlu receptors and dopamine systems. A variety of approaches have been used to study these interactions on the cellular, electrophysiological, and behavi
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Co-labeling of Neuronal Cells Using DiI Neuronal Filling and Immunohistochemistry to Explore Metaboc and responsive to neurotransmitter binding, such as glutamate. It is clear that structural plasticity is related to changes in synaptic efficacy, which is heavily mediated by receptor expression. Using a combination of diolistic labeling of neurons using lipophilic fluorescent dye and immunohistoc
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